Disulphide formation on mitochondrial protein thiols
| العنوان: | Disulphide formation on mitochondrial protein thiols |
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| المؤلفون: | Thomas R. Hurd, Michael P. Murphy, Aleksandra Filipovska, Nikola J. Costa, Christina C. Dahm |
| المصدر: | Biochemical Society Transactions. 33:1390-1393 |
| بيانات النشر: | Portland Press Ltd., 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Physiological significance, Chemistry, Cell, Endogeny, Glutathione, Mitochondrion, Protein glutathionylation, Biochemistry, Redox, chemistry.chemical_compound, medicine.anatomical_structure, medicine, Mitochondrial protein |
| الوصف: | A large number of proteins contain free thiols that can be modified by the formation of internal disulphides or by mixed disulphides with low-molecular-mass thiols. The majority of these latter modifications result from the interaction of protein thiols with the endogenous glutathione pool. Protein glutathionylation and disulphide formation are of significance both for defence against oxidative damage and in redox signalling. As mitochondria are central to both oxidative damage and redox signalling within the cell, these modifications of mitochondrial proteins are of particular importance. In the present study, we review the mechanisms and physiological significance of these processes. |
| تدمد: | 1470-8752 0300-5127 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ae247bc3437aa0a83b0c2d34974dbTest https://doi.org/10.1042/bst0331390Test |
| رقم الانضمام: | edsair.doi...........2a6ae247bc3437aa0a83b0c2d34974db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708752 03005127 |
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