دورية أكاديمية
Therapeutic targeting of TRAIL death receptors
| العنوان: | Therapeutic targeting of TRAIL death receptors |
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| المؤلفون: | Di Cristofano, Francesca, George, Andrew, Tajiknia, Vida, Ghandali, Maryam, Wu, Laura, Zhang, Yiqun, Srinivasan, Praveen, Strandberg, Jillian, Hahn, Marina, Sanchez Sevilla Uruchurtu, Ashley, Seyhan, Attila A., Carneiro, Benedito A., Zhou, Lanlan, Huntington, Kelsey E., El-Deiry, Wafik S. |
| المصدر: | Biochemical Society Transactions ; volume 51, issue 1, page 57-70 ; ISSN 0300-5127 1470-8752 |
| بيانات النشر: | Portland Press Ltd. |
| سنة النشر: | 2023 |
| الوصف: | The discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the development of TRAIL receptor agonists (TRAs), including recombinant human TRAIL (rhTRAIL) and TRAIL receptor-targeted agonistic antibodies. While such TRAIL pathway-targeted therapies showed promise in preclinical data and clinical trials have been conducted, none have advanced to FDA approval. Subsequent second-generation approaches focused on improving upon the specific limitations of first-generation approaches by ameliorating the pharmacokinetic profiles and agonistic abilities of TRAs as well as through combinatorial approaches to circumvent resistance. In this review, we summarize the successes and shortcomings of first- and second-generation TRAIL pathway-based therapies, concluding with an overview of the discovery and clinical introduction of ONC201, a compound with a unique mechanism of action that represents a new generation of TRAIL pathway-based approaches. We discuss preclinical and clinical findings in different tumor types and provide a unique perspective on translational directions of the field. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1042/bst20220098 |
| الإتاحة: | https://doi.org/10.1042/bst20220098Test https://portlandpress.com/biochemsoctrans/article-pdf/51/1/57/943088/bst-2022-0098c.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.452A0D5D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1042/bst20220098 |
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