دورية أكاديمية
Modelling early responses to neurodegenerative mutations in mice
| العنوان: | Modelling early responses to neurodegenerative mutations in mice |
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| المؤلفون: | Gilley, Jonathan, Adalbert, Robert, Coleman, Michael P. |
| المصدر: | Biochemical Society Transactions ; volume 39, issue 4, page 933-938 ; ISSN 0300-5127 1470-8752 |
| بيانات النشر: | Portland Press Ltd. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Biochemistry |
| الوصف: | Considering the many differences between mice and humans, it is perhaps surprising how well mice model late-onset human neurodegenerative disease. Models of Alzheimer's disease, frontotemporal dementia, Parkinson's disease and Huntington's disease show some striking similarities to the corresponding human pathologies in terms of axonal transport disruption, protein aggregation, synapse loss and some behavioural phenotypes. However, there are also major differences. To extrapolate from mouse models to human disease, we need to understand how these differences relate to intrinsic limitations of the mouse system and to the effects of transgene overexpression. In the present paper, we use examples from an amyloid-overexpression model and a mutant-tau-knockin model to illustrate what we learn from each type of approach and what the limitations are. Finally, we discuss the further contributions that knockin and similar approaches can make to understanding pathogenesis and how best to model disorders of aging in a short-lived mammal. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1042/bst0390933 |
| الإتاحة: | https://doi.org/10.1042/bst0390933Test https://portlandpress.com/biochemsoctrans/article-pdf/39/4/933/548365/bst0390933.pdfTest |
| رقم الانضمام: | edsbas.F2C0437C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1042/bst0390933 |
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