التفاصيل البيبلوغرافية
| العنوان: |
Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension |
| المؤلفون: |
Rodrigo Salinas, Ramón, Prat Martorell, Hernán, Passalacqua Rivanera, Walter, Araya, Julia, Bachler, Jean P. |
| بيانات النشر: |
PORTLAND PRESS LTD |
| سنة النشر: |
2008 |
| المجموعة: |
Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: |
antioxidant status |
| الوصف: |
Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated with a decrease in BP (blood pressure) in patients with EH. A randomized doubleblind placebo-controlled clinical trial was conducted in 110 men with grade 1 EH (35–60 years of age without obesity, dyslipidaemia and diabetes mellitus, non-smokers, not undergoing vigorous physical exercise, without the use of any medication and/or high consumption of fruit and vegetables). Participants were randomly assigned to receive either vitamins C+E [vitamin C (1 g/day) plus vitamin E (400 international units/day)] or placebo for 8 weeks. Measurements included 24 h ambulatory BP and blood analysis of oxidative-stress-related parameters in erythrocytes (GSH/GSSH ratio, antioxidant enzymes and malondialdehyde) and plasma [FRAP (ferric reducing ability of plasma)], and levels of 8-isoprostane, vitamins C and E were measured at baseline and after treatment. Following administration of vitamins C+E, patients with EH had significantly lower systolic BP, diastolic BP and mean arterial BP and higher erythrocyte and serum antioxidant capacity compared with either placebo-treated patients with EH or the patients with EH at baseline prior to treatment. BP correlated positively with plasma 8-isoprostane levels and negatively with plasma FRAP levels in the vitamins C+E- and placebo-treated groups. In conclusion, the present study supports the view that oxidative stress is involved in the pathogenesis of EH, and that enhancement of antioxidant status by supplementation with vitamins C and E in patients with EH is associated with lower BP. This suggests intervention with antioxidants as an adjunct therapy for hypertension. ; We thank the Fondo Nacional de Investigaci ón Científica y Tecnológica (FONDECYT; grant number 1040429 and 1070948) |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0143-5221 |
| العلاقة: |
CLINICAL SCIENCE, Volume: 114, Issue: 9-10, Pages: 625-634, 2008; http://repositorio.uchile.cl/handle/2250/128212Test |
| الإتاحة: |
http://repositorio.uchile.cl/handle/2250/128212Test |
| رقم الانضمام: |
edsbas.736C0E6C |
| قاعدة البيانات: |
BASE |
