دورية أكاديمية
The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester potentiates insulin secretion stimulated by glucose and L-arginine independently of its action on ATP-sensitive K+ channels
| العنوان: | The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester potentiates insulin secretion stimulated by glucose and L-arginine independently of its action on ATP-sensitive K+ channels |
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| المؤلفون: | Salehi, S Albert, Parandeh, Fariborz, Lundquist, Ingmar |
| المصدر: | Bioscience Reports; 18(1), pp 19-28 (1998) ; ISSN: 0144-8463 |
| بيانات النشر: | Portland Press |
| سنة النشر: | 1998 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Endocrinology and Diabetes, Insulin and glucagon secretion, isolated mouse islets, nitric oxide synthase, NG-nitro-L-arginine methyl ester, L-arginine, diazoxide, glucose, high K+ |
| الوصف: | The nature of the action of the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on hormone release from isolated islets was investigated. We found that glucose-induced insulin release was potentiated by L-NAME in the absence or presence of diazoxide, a potent K+ATP channel opener, as well as in the presence of diazoxide plus a depolarizing concentration of K+. At a low, physiological glucose concentration L-NAME did not influence insulin secretion induced by K+ but inhibited glucagon secretion. L-arginine-induced insulin release was potentiated by L-NAME. This potentiation was observed also in the presence of K+ plus diazoxide. Further, glucagon release induced by L-arginine as well as by L-arginine plus K+ and diazoxide was suppressed by L-NAME. The results strongly suggest that the L-NAME-induced potentiation of insulin secretion in response to glucose or L-arginine as well as the inhibitory effects on glucagon secretion are largely mediated by L-NAME directly suppressing islet NOS activity. Hence NO apparently affects insulin and glucagon secretion independently of membrane depolarization events. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/1113492Test; http://dx.doi.org/10.1023/A:1022288600348Test; pmid:9653515; scopus:0031817046 |
| DOI: | 10.1023/A:1022288600348 |
| الإتاحة: | https://doi.org/10.1023/A:1022288600348Test https://lup.lub.lu.se/record/1113492Test |
| رقم الانضمام: | edsbas.E93D67B7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1023/A:1022288600348 |
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