التفاصيل البيبلوغرافية
| العنوان: |
QUERCETIN ATTENUATES OXIDATIVE STRESS, INFLAMMATION AND CARDIAC DYSFUNCTION IN ACRYLAMIDE-INDUCED CARDIOTOXICITY. |
| المؤلفون: |
SINGH, TARANBIR, SHIVANANDAPPA, THIPPESWAMY BOREDDY, KUSHWAH, AJAY SINGH |
| المصدر: |
Acta Poloniae Pharmaceutica; Mar/Apr2020, Vol. 77 Issue 2, p343-352, 10p |
| مصطلحات موضوعية: |
QUERCETIN, OXIDATIVE stress, CARDIOTOXICITY, INFLAMMATION, ACRYLAMIDE, CYTOKINES |
| مستخلص: |
Acrylamide (ACR) is a foodborne toxic agent, formed in food when processed at high temperature. This study aimed at evaluating the biochemical changes induced by ACR and the effect of quercetin as a treatment against ACR induced cardiotoxicity in rats. Wistar rats of either gender (n = 6) were divided into four groups; (i) normal vehicle control, (ii) ACR control group 6 mg/kg i.p. daily (iii) ACR + quercetin treatment group (25 mg/kg p.o.) and (iv) ACR + quercetin treatment group (50 mg/kg p.o.). Routinely general diagnostics characters were assessed daily. At the end of the study (after four weeks) hemodynamic parameters were evaluated and blood samples were collected for estimation of biochemical parameters. The rats were decapitated, their hearts excised, cleaned and weighed. Cardiac homogenate was used to determine antioxidants and oxidative levels. Histopathological evaluations were carried out to determine ACR induced changes. Acrylamide (ACR) treated control rats group show remarkably altered general characteristics and also had elevated markers for myocardial damage, altered hemodynamics, deranged oxidative stress level, increased expression of inflammatory cytokines and also alter histopathological remarkable changes (P < 0.05) as compared with vehicle control group. Treatment with quercetin at 25 and 50 mg/kg reversed the above changes significantly (P < 0.05), the higher dose being more effective. The present study concluded that quercetin protects against ACR-induced cardiotoxicity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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