دورية أكاديمية
Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study
| العنوان: | Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study |
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| المؤلفون: | Jiang, Sisi, Yan, Hao, Chen, Qiang, Tian, Lin, Lu, Tianlan, Tan, Hao-Yang, Yan, Jun, Zhang, Dai |
| المساهمون: | Zhang, D (reprint author), Peking Univ, Hosp 6, Beijing 100191, Peoples R China., Peking Univ, Hosp 6, Beijing 100191, Peoples R China., Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China., Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China., Lieber Inst Brain Dev, Baltimore, MD USA., Johns Hopkins Univ, Sch Med, Psychiat & Behav Sci, Baltimore, MD USA., Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China., Peking Univ Tsinghua Univ Joint Ctr Life Sci, Beijing 100871, Peoples R China., Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | PLOS ONE |
| سنة النشر: | 2015 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | DORSOLATERAL PREFRONTAL CORTEX, COGNITIVE DEFICITS, 1ST-EPISODE SCHIZOPHRENIA, INTERMEDIATE PHENOTYPES, NONPSYCHOTIC RELATIVES, BRAIN ACTIVATION, GENE-EXPRESSION, METAANALYSIS, DYSFUNCTION, RISK |
| الوصف: | Background It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many functional magnetic resonance imaging (fMRI) studies. This study investigated how brain region activation was altered in schizophrenia and how it was inherited independently from performance deficits. Method The authors used fMRI method during N-back task to assess working memory related cortical activation in four groups (N = 20 in each group, matching task performance, age, gender and education): schizophrenic patients, their unaffected biological parents, young healthy controls for the patients and older healthy controls for their parents. Results Compared to healthy controls, patients showed an exaggerated response in the right dorsolateral prefrontal cortex (brodmann area [BA] 46) and bilateral ventrolateral prefrontal cortex, and had reduced activation in bilateral dorsolateral prefrontal cortex (BA 9). In the conjunction analysis, the effect of genetic risk (parents versus older control) shared significantly overlapped activation with effect of disease (patients versus young control) in the right middle frontal gyrus (BA 46) and left inferior parietal gyrus (BA 40). Conclusions Physiological inefficiency of dorsal prefrontal cortex and compensation involvement of ventral prefrontal cortex in working memory function may one physiological characteristics of schizophrenia. And relatively inefficient activation in dorsolateral prefrontal cortex probably can be a promising intermediate phenotype for schizophrenia. ; National Basic Research Program of China [2011CB707805]; National Natural Science Foundation of China [81370032, 91232305, 81361120395, 91432304] ; SCI(E) ; PubMed ; ARTICLE ; daizhang@bjmu.edu.cn ; 8 ; e0135468 ; 10 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 26270056 |
| العلاقة: | PLOS ONE.2015,10,(8).; 1295003; http://hdl.handle.net/20.500.11897/417202Test; WOS:000359492800078 |
| DOI: | 10.1371/journal.pone.0135468 |
| الإتاحة: | https://doi.org/20.500.11897/417202Test https://doi.org/10.1371/journal.pone.0135468Test https://hdl.handle.net/20.500.11897/417202Test |
| رقم الانضمام: | edsbas.A14CE4A0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 26270056 |
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| DOI: | 10.1371/journal.pone.0135468 |