Diversity across major and candidate genes in European local pig breeds
| العنوان: | Diversity across major and candidate genes in European local pig breeds |
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| المؤلفون: | Radomir Savić, Riccardo Bozzi, Marjeta Čandek-Potokar, Juliette Riquet, José Pedro Araújo, María Muñoz, Goran Kušec, Čedomir Radović, Ana Isabel Fernández, Estefania Alves, Jordi Estellé, Fabián García, Marie J. Mercat, Rui Charneca, Alessandro Crovetti, Christoph Zimmer, Danijel Karolyi, Luca Fontanesi, Juan García-Casco, Maurizio Gallo, J.M. Martins, Ivona Djurkin-Kušec, Martin Škrlep, Raquel Quintanilla, Cristina Óvilo, Violeta Razmaite, Yolanda Núñez, J. Tibau, Claudia Geraci |
| المساهمون: | Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA), Department of Agricultural and Food Sciences, University of Bologna, Kmetijski Institut Slovenije, Partenaires INRAE, Universidade de Évora, Institute of Agrifood Research and Technology (IRTA), J.J. Strossmayer University of Osijek, Institut du Porc (IFIP), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Bäuerliche Erzeugergemeinschaft Schwäbisch Hall (BESH), Lithuanian University of Health Science (LUSH), Instituto Politécnico de Viana do Castelo, Faculty of Agriculture, Université nationale du Rwanda, Department of Animal Science, Faculty of Agriculture, University of Ghana, Associazione Nazionale Allevatori Suini, Slovenian Research Agency P4-0133, European Project: 634476,H2020,H2020-SFS-2014-2,TREASURE(2015), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Producció Animal, Genètica i Millora Animal, Università degli Studi di Firenze = University of Florence (UniFI), University of Bologna/Università di Bologna, Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT), Instituto Politécnico de Viana do Castelo = Polytechnic Institute of Viana do Castelo (IPVC), Muñoz, María, Bozzi, Riccardo, García, Fabián, Núñez, Yolanda, Geraci, Claudia, Crovetti, Alessandro, García-Casco, Juan, Alves, Estefania, Škrlep, Martin, Charneca, Rui, Martins, Jose M., Quintanilla, Raquel, Tibau, Joan, Kušec, Goran, Djurkin-Kušec, Ivona, Mercat, Marie J., Riquet, Juliette, Estellé, Jordi, Zimmer, Christoph, Razmaite, Violeta, Araujo, Jose P., Radović, Čedomir, Savić, Radomir, Karolyi, Danijel, Gallo, Maurizio, Čandek-Potokar, Marjeta, Fontanesi, Luca, Fernández, Ana I., Óvilo, Cristina |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP PLoS ONE, Vol 13, Iss 11, p e0207475 (2018) PloS one PLOS ONE PLoS ONE PLoS ONE, Public Library of Science, 2018, 13 (11), ⟨10.1371/journal.pone.0207475⟩ Plos One PloS one, vol. 13, no. 11, pp. 1-30, 2018. IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) PLoS ONE, 2018, 13 (11), ⟨10.1371/journal.pone.0207475⟩ Repositorio de Resultados de Investigación del INIA Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA Plos One 11 (13), . (2018) INIA: Repositorio de Resultados de Investigación del INIA |
| بيانات النشر: | PLOS One, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | pig, European People, Swine, IGF2-INTRON3-G3072A SUBSTITUTION, Population genetics, Lithuanian People, Breeding, Biochemistry, FATTY-ACID-COMPOSITION, PORCINE, genetic structure, Ethnicities, Animal Husbandry, lcsh:Science, reproductive traits, Mammals, education.field_of_study, pig breeds, Eukaryota, Lipids, Breed, Alentejana, PROMOTER REGION, Genetic diversity, pig, candidate genes, local breeds, SNPs, Genetic structure, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Genotype, Quantitative Trait Loci, Quantitative Trait Loci / genetics, Candidate genes, 03 medical and health sciences, Genetic, Genetics, education, ESTROGEN-RECEPTOR LOCUS, Alleles, Genetic association, BACKFAT THICKNESS, lcsh:R, Organisms, 0402 animal and dairy science, Biology and Life Sciences, meat quality trait, estrogen receptor locus, genetic, feed-intake, coat color, mutations, 040201 dairy & animal science, 030104 developmental biology, Genetics, Population, Food, Genetic Loci, Evolutionary biology, Mutation, Population Groupings, lcsh:Q, Population Genetics, 0301 basic medicine, Candidate gene, lcsh:Medicine, meat quality, Fats, Animal Products, Medicine and Health Sciences, Animal Management, 2. Zero hunger, Multidisciplinary, pigs, Agriculture, 04 agricultural and veterinary sciences, productive traits, disease resistance traits, Phenotype, Vertebrates, Polymorphism, Single Nucleotide / genetics, Autre (Sciences du Vivant), Research Article, Meat, Population, pig morphological traits, SNP, Biology, Polymorphism, Single Nucleotide, candidate mutations, udc:636, MC4R GENE, Animals, Nutrition, Evolutionary Biology, Genetic diversity, Population Biology, MEAT QUALITY TRAITS, biology.organism_classification, Diet, causal mutations, Spain, Amniotes, People and Places, local breed, marker, Local breeds |
| الوصف: | The aim of this work was to analyse the distribution of causal and candidate mutations associated to relevant productive traits in twenty local European pig breeds. Also, the potential of the SNP panel employed for elucidating the genetic structure and relationships among breeds was evaluated. Most relevant genes and mutations associated with pig morphological, productive, meat quality, reproductive and disease resistance traits were prioritized and analyzed in a maximum of 47 blood samples from each of the breeds (Alentejana, Apulo- Calabrese, Basque, Bísara, Majorcan Black, Black Slavonian (Crna slavonska), Casertana, Cinta Senese, Gascon, Iberian, Krškopolje (Krškopoljski), Lithuanian indigenous wattle, Lithuanian White Old Type, Mora Romagnola, Moravka, Nero Siciliano, Sarda, Schwäbisch-Hällisches Schwein (Swabian Hall pig), Swallow-Bellied Mangalitsa and Turopolje). We successfully analyzed allelic variation in 39 polymorphisms, located in 33 candidate genes. Results provide relevant information regarding genetic diversity and segregation of SNPs associated to production and quality traits. Coat color and morphological trait-genes that show low level of segregation, and fixed SNPs may be useful for traceability. On the other hand, we detected SNPs which may be useful for association studies as well as breeding programs. For instance, we observed predominance of alleles that might be unfavorable for disease resistance and boar taint in most breeds and segregation of many alleles involved in meat quality, fatness and growth traits. Overall, these findings provide a detailed catalogue of segregating candidate SNPs in 20 European local pig breeds that may be useful for traceability purposes, for association studies and for breeding schemes. Population genetic analyses based on these candidate genes are able to uncover some clues regarding the hidden genetic substructure of these populations, as the extreme genetic closeness between Iberian and Alentejana breeds and an uneven admixture of the breeds studied. The results are in agreement with available knowledge regarding breed history and management, although largest panels of neutral markers should be employed to get a deeper understanding of the population’s structure and relationships. |
| وصف الملف: | application/pdf; ELETTRONICO |
| اللغة: | Portuguese |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeded6aafb23e21442f0793dca84e4cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4eeded6aafb23e21442f0793dca84e4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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