Metabolic Syndrome, Neurotoxic 1-Deoxysphingolipids and Nervous Tissue Inflammation in Chronic Idiopathic Axonal Polyneuropathy (CIAP)
| العنوان: | Metabolic Syndrome, Neurotoxic 1-Deoxysphingolipids and Nervous Tissue Inflammation in Chronic Idiopathic Axonal Polyneuropathy (CIAP) |
|---|---|
| المؤلفون: | Philip Van Damme, Gergely Karsai, Larissa Hube, Kristl G. Claeys, Thorsten Hornemann, Jörg B. Schulz, Joachim Weis, Maike F. Dohrn, Sarah Hirshman |
| المساهمون: | Nógrádi, Antal, University of Zurich |
| المصدر: | PLOS ONE 12(1), e0170583 (2017). doi:10.1371/journal.pone.0170583 PLoS ONE PLoS one 12(1), e0170583-(2017). doi:10.1371/journal.pone.0170583 PLoS ONE, Vol 12, Iss 1, p e0170583 (2017) |
| بيانات النشر: | PLoS, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pathology, Physiology, Biopsy, lcsh:Medicine, Blood Pressure, Pathology and Laboratory Medicine, Vascular Medicine, Biochemistry, Epithelium, 0302 clinical medicine, Diabetic Neuropathies, Glucose Metabolism, Animal Cells, 540 Chemistry, Electroneuronography, Medicine and Health Sciences, lcsh:Science, 10038 Institute of Clinical Chemistry, Metabolic Syndrome, Multidisciplinary, CD68, Hematology, Middle Aged, Lipids, 3. Good health, Body Fluids, medicine.anatomical_structure, Blood, Hyperlipidemia, Carbohydrate Metabolism, Female, ddc:500, medicine.symptom, Anatomy, Cellular Types, Polyneuropathy, Research Article, medicine.medical_specialty, Hypercholesterolemia, 610 Medicine & health, Sural nerve, Inflammation, Surgical and Invasive Medical Procedures, 1100 General Agricultural and Biological Sciences, Blood Plasma, 03 medical and health sciences, Polyneuropathies, Signs and Symptoms, 1300 General Biochemistry, Genetics and Molecular Biology, Diagnostic Medicine, medicine, Humans, Aged, 1000 Multidisciplinary, Sphingolipids, business.industry, Nervous tissue, lcsh:R, Microangiopathy, Biology and Life Sciences, Endothelial Cells, Epithelial Cells, Cell Biology, medicine.disease, Axons, 030104 developmental biology, Biological Tissue, Metabolism, Case-Control Studies, Metabolic Disorders, Chronic Disease, lcsh:Q, Metabolic syndrome, business, 030217 neurology & neurosurgery |
| الوصف: | AIM: Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive, predominantly sensory, axonal polyneuropathy, with no aetiology being identified despite extensive investigations. We studied the potential role of the metabolic syndrome, neurotoxic 1-deoxysphingolipids (1-deoxySLs), microangiopathy and inflammation in sural nerve biopsies. METHODS: We included 30 CIAP-patients, 28 with diabetic distal symmetrical polyneuropathy (DSPN) and 31 healthy controls. We assessed standardised scales, tested for the metabolic syndrome, measured 1-deoxySLs in plasma, performed electroneurography and studied 17 sural nerve biopsies (10 CIAP; 7 DSPN). RESULTS: One third of the CIAP-patients had a metabolic syndrome, significantly less frequent than DSPN-patients (89%). Although the metabolic syndrome was not significantly more prevalent in CIAP compared to healthy controls, hypercholesterolemia did occur significantly more frequent. 1-deoxySLs were significantly and equally elevated in both patient groups compared to healthy controls. Mean basal lamina thickness of small endoneurial vessels and the number of CD68- or CD8-positive cells in biopsies of CIAP- and DSPN-patients did not differ significantly. However, the number of leucocyte-common-antigen positive cells was significantly increased in CIAP. CONCLUSIONS: A non-significant trend towards a higher occurrence of the metabolic syndrome in CIAP-patients compared to healthy controls was found. 1-deoxySLs were significantly increased in plasma of CIAP-patients. Microangiopathy and an inflammatory component were present in CIAP-biopsies. ispartof: PLoS One vol:12 issue:1 ispartof: location:United States status: published |
| وصف الملف: | Electronic-eCollection; 0170583.pdf - application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991be78222263ab6e5e2e33afadbcda0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....991be78222263ab6e5e2e33afadbcda0 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |