New heterocyclic derivatives of trifluoroalanine
| العنوان: | New heterocyclic derivatives of trifluoroalanine |
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| المؤلفون: | T. V. Goreva, A. Yu. Aksinenko, V. B. Sokolov, T. A. Epishina |
| المصدر: | Russian Journal of General Chemistry. 84:1358-1361 |
| بيانات النشر: | Pleiades Publishing Ltd, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | chemistry.chemical_compound, Hydrolysis, Trifluoromethyl, chemistry, Organic chemistry, General Chemistry, Heterocyclic derivatives, Benzamidine |
| الوصف: | A new method of the synthesis of heterocyclic derivatives of trifluoroalanine based on the cyclocondensation of methyl trifluoropyruvate tert-butoxycarbonylimine with C,N- and N,N-binucleophiles, like Nsubstituted ureas, 1-benzyl-6-aminouracil, benzamidine, and 3-aminocrotononitrile, followed by hydrolysis of the resulting Boc-derivatives to 5-amino-5-trifluoromethylimidazolidine-2,4-diones, 5-amino-5-trifluoromethyl-1-benzyl-5,7-dihydropyrrolo[2,3-d]-pyrimidine-2,4,6-3H-trione, 4-amino-2-methyl-5-oxo-4-(trifluoromethyl)-4,5-dihydro-1H-pyrrole-3-carbonitrile, or 5-amino-5-trifluoromethyl-2-phenyl-3,5-dihydroimidazol-4-one, respectively, was developed. |
| تدمد: | 1608-3350 1070-3632 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3aabcd6721289da9cdecfa85fef20f41Test https://doi.org/10.1134/s1070363214070184Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........3aabcd6721289da9cdecfa85fef20f41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16083350 10703632 |
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