Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity
| العنوان: | Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity |
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| المؤلفون: | Hitendra S. Joshi, Tejal D. Bhatt, Vimal H. Kapupara, Sanjay D. Hadiyal, Prakash L. Kalavadiya, Dinesh G. Gojiya |
| المصدر: | Russian Journal of Bioorganic Chemistry. 46:803-813 |
| بيانات النشر: | Pleiades Publishing Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Pyrimidine, 010405 organic chemistry, Organic Chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Cycloaddition, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Ultrasonic assisted, Bioorganic chemistry, Cancer cell lines, Heterocyclic derivatives |
| الوصف: | In the presents work synthesis and characterization of new heterocyclic derivatives containing pyrazolo[3,4-d]pyrimidine linkage with 1,4-disubstituted-1,2,3-triazoles via methylene-oxy group. The selected synthesized compounds were tested for their in-vitro anticancer activity against various cancer cell lines. Synthesis of compounds was done under ultrasonic-assisted Huisgen 1,3-dipolar cycloaddition reaction with good yields. Some of the newly synthesized compounds demonstrated good to moderate anticancer activity, most of compounds shows activity against renal cancer cell lines. |
| تدمد: | 1608-330X 1068-1620 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f6be2f602b2440935e08e54b0aa391f5Test https://doi.org/10.1134/s1068162020050106Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........f6be2f602b2440935e08e54b0aa391f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1608330X 10681620 |
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