Evidence of incompatibility for topical anionic agents used in conjunc-tion with chlorhexidine gluconate: A systematic review
| العنوان: | Evidence of incompatibility for topical anionic agents used in conjunc-tion with chlorhexidine gluconate: A systematic review |
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| المؤلفون: | William A Budris, Finola M. Bruins, Najeah Ahmad, Alba Posligua, T. Huynh, Beatrice Nardone, Dennis P. West, Gary Tran, Josh A. Hammel |
| المصدر: | Journal of Surgical Dermatology, Vol 1, Iss 2 (2016) |
| بيانات النشر: | PiscoMed Publishing Pte Ltd, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | skin, Acrylate, Chemistry, Chlorhexidine, reduced antibacterial activity, lcsh:Surgery, lcsh:RD1-811, incompatibility, precipitation, lcsh:RL1-803, chemistry.chemical_compound, systematic review, Topical agents, Triethanolamine, Sodium hypochlorite, Chlorhexidine gluconate, lcsh:Dermatology, medicine, Organic chemistry, inactivation, Limited evidence, Antibacterial activity, medicine.drug |
| الوصف: | Chlorhexidine gluconate (CHG) is a widely used antiseptic agent for skin and wound disinfection. The cationic properties of CHG may allow its inactivation and precipitation by anionic agents in commonly used topical agents. We conducted a systematic review by searching through PubMed, Cochrane Library, and Web of Science databases and selected original research articles reporting on CHG incompatibility, defined as inactivation or precipitation. The search yielded 22 publications that demonstrated CHG incompatibility via: 1) reduced antibacterial activity (carbomer, acrylates/C10-C30 alkyl acrylate crosspolymer, dentin, bovine serum albumin, copolymer M239144, sodium lauryl sulfate, heat-killed microbes, triethanolamine, and bark cork); and 2) visible precipitate formation (sodium hypochlorite, EDTA, saline, ethanol, andnystatin). Only three publications reported on CHG incompatibility in dermatology, specifically for carbomer, triethanolamine, and acrylates/C10-C30 alkyl acrylate crosspolymer. Although limited evidence linking CHG incompatibility and anionic agents exists, clinicians should carefully consider the nature of topical agents used if CHG is concurrently applied. Increased awareness of CHG incompatibility may result in better antibacterial activity thus ensuring optimal patient management. |
| تدمد: | 2424-9165 2424-9084 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1c67267e76484f4cf53ad0ac80d8d8Test https://doi.org/10.18282/jsd.v1.i2.21Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0d1c67267e76484f4cf53ad0ac80d8d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24249165 24249084 |
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