Slow Wave Sleep-inducing Effects of First Generation H1-Antagonists
| العنوان: | Slow Wave Sleep-inducing Effects of First Generation H1-Antagonists |
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| المؤلفون: | Yukio Sugimoto, Zhong Chen, Yoshio Kaneko, Chiaki Kamei, Koichi Saitou |
| المصدر: | Biological and Pharmaceutical Bulletin. 22:1079-1082 |
| بيانات النشر: | Pharmaceutical Society of Japan, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, Chlorpheniramine, medicine.medical_specialty, medicine.drug_class, Pharmaceutical Science, Hypnotic, Internal medicine, Insomnia, Animals, Hypnotics and Sedatives, Medicine, Rats, Wistar, Pyrilamine, Slow-wave sleep, Pharmacology, business.industry, Brotizolam, Electroencephalography, Azepines, General Medicine, Sleep in non-human animals, Rats, Promethazine, Diphenhydramine, Endocrinology, Anesthesia, Sedative, Histamine H1 Antagonists, medicine.symptom, Sleep, business, medicine.drug |
| الوصف: | The present study was performed to see if first-generation histamine H1-antagonists are useful sedative-hypnotic drugs. Increases in electroencephalogram (EEG) power spectra of the delta band (0-4 Hz) at the frontal cortex and theta band (4-8 Hz) at the hippocampus in rats were used as an indexes of sleep. The H1-antagonists used in this study resulted in a decrease in sleep latency and an increase in sleep duration (slow wave sleep). The rate of REM (rapid eye movement) sleep during slow wave sleep was decreased by H1-antagonists and brotizolam. The order of potency of H1-antagonists for the reduction in sleep latency (from greatest to least) was promethazine>chlorpheniramine>diphenhydramine and pyrilamine, and that for the increase in sleep duration was chlorpheniramine>promethazine>diphenhydramine and pyrilamine. Brotizolam was more potent than these H1-antagonists, with 14-18-fold and 4-14-fold greater effects on sleep latency and duration, respectively. These results clearly show that H1-antagonists are effective in mild to moderate insomnia as sedative-hypnotic drugs. |
| تدمد: | 1347-5215 0918-6158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0490a49c2d38e54a6841882701e20169Test https://doi.org/10.1248/bpb.22.1079Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0490a49c2d38e54a6841882701e20169 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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