دورية أكاديمية
In vitro toxicity of carbon nanotubes, nano-graphite and carbon black, similar impacts of acid functionalization
| العنوان: | In vitro toxicity of carbon nanotubes, nano-graphite and carbon black, similar impacts of acid functionalization |
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| المؤلفون: | Figarol, Agathe, Pourchez, Jérémie, Boudard, Delphine, Forest, Valérie, Akono, Céline, TULLIANI, Jean Marc Christian, Lecompte, Jean Pierre, Cottier, Michèle, Bernache Assollant, Didier, Grosseau, Philippe |
| المساهمون: | Figarol, Agathe, Pourchez, Jérémie, Boudard, Delphine, Forest, Valérie, Akono, Céline, Tulliani, Jean Marc Christian, Lecompte, Jean Pierre, Cottier, Michèle, Bernache Assollant, Didier, Grosseau, Philippe |
| بيانات النشر: | Pergamon-Elsevier Science Ltd |
| سنة النشر: | 2015 |
| المجموعة: | PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino) |
| مصطلحات موضوعية: | Acid functionalization, Biological toxicity, Carbon black, Carbon nanotube, Graphene, Nano-graphite |
| الوصف: | Carbon nanotubes (CNT) and nano-graphite (NG) are graphene-based nanomaterials which share exceptional physicochemical properties, but whose health impacts are unfortunately still not well understood. On the other hand, carbon black (CB) is a conventional and widely studied material. The comparison of these three carbon-based nanomaterials is thus of great interest to improve our understanding of their toxicity. An acid functionalization was carried out on CNT, NG and CB so that, after a thorough characterization, their impacts on RAW 264.7 macrophages could be compared for a similar surface chemistry (15 to 120 μg·mL-1 nanomaterials, 90-min to 24-h contact). Functionalized nanomaterials triggered a weak cytotoxicity similar to the pristine nanomaterials. Acid functionalization increased the pro-inflammatory response except for CB which did not trigger any TNF-α production before or after functionalization, and seemed to strongly decrease the oxidative stress. The toxicological impact of acid functionalization appeared thus to follow a similar trend whatever the carbon-based nanomaterial. At equivalent dose expressed in surface and equivalent surface chemistry, the toxicological responses from murine macrophages to NG were higher than for CNT and CB. It seemed to correspond to the hypothesis of a platelet and fiber paradigm. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000367635500029; volume:30; issue:1; firstpage:476; lastpage:485; numberofpages:10; journal:TOXICOLOGY IN VITRO; http://hdl.handle.net/11583/2650956Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84953388745 |
| DOI: | 10.1016/j.tiv.2015.09.014Document |
| الإتاحة: | https://doi.org/10.1016/j.tiv.2015.09.014DocumentTest http://hdl.handle.net/11583/2650956Test |
| رقم الانضمام: | edsbas.AECC8DDC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.tiv.2015.09.014Document |
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