دورية أكاديمية
Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain
| العنوان: | Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain |
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| المؤلفون: | Fitzgerald, D. P., Cole, S. J., Hammond, A., Seaman, C., Cooper, H. M. |
| المساهمون: | D. G. Amaral |
| بيانات النشر: | Pergamon |
| سنة النشر: | 2006 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Neurosciences, Cortical Development, Radial Glia, Tangential Migration, Interneuron, Netrin, Rgma, Medial Ganglionic Eminence, Developing Cerebral-cortex, Mammalian Telencephalon, Cortical Interneurons, Neuronal Migration, Colorectal-cancer, Receptor Neogenin, Netrin Receptor, Nervous-system, 320704 Cellular Nervous System, C1, 730104 Nervous system and disorders, 1109 Neurosciences |
| الوصف: | Many studies have demonstrated a role for netrin-1-deleted in colorectal cancer (DCC) interactions in both axon guidance and neuronal migration. Neogenin, a member of the DCC receptor family, has recently been shown to be a chemorepulsive axon guidance receptor for the repulsive guidance molecule (RGM) family of guidance cues [Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, Chedotal A, Mueller B, Strittmatter S (2004) Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 6:755-762]. Here we show that neogenin is present on neural progenitors, including neurogenic radial glia, in the embryonic mouse forebrain suggesting that neogenin expression is a hallmark of neural progenitor populations. Neogenin-positive progenitors were isolated from embryonic day 14.5 forebrain using flow cytometry and cultured as neurospheres. Neogenin-positive progenitors gave rise to neurospheres displaying a high proliferative and neurogenic potential. In contrast, neogenin-negative forebrain cells did not produce long-term neurosphere cultures and did not possess a significant neurogenic potential. These observations argue strongly for a role for neogenin in neural progenitor biology. In addition, we also observed neogenin on parvalbumin- and calbindin-positive interneuron neuroblasts that were migrating through the medial and lateral ganglionic eminences, suggesting a role for neogenin in tangential migration. Therefore, neogenin may be a multi-functional receptor regulating both progenitor activity and neuroblast migration in the embryonic forebrain. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0306-4522 |
| العلاقة: | orcid:0000-0001-5078-2248; orcid:0000-0001-9838-5743 |
| الإتاحة: | https://doi.org/10.1016/j.neuroscience.2006.06.041Test https://espace.library.uq.edu.au/view/UQ:79684Test |
| رقم الانضمام: | edsbas.37A6838C |
| قاعدة البيانات: | BASE |
| تدمد: | 03064522 |
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