دورية أكاديمية
Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population
| العنوان: | Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population |
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| المؤلفون: | Peng Huang, Jing-Jing Wu, Jin-Wei Zhang, Yu-Qing Hou, Ping Zhu, Rong Yin, Rong-Bin Yu, Yun Zhang, Ming Yue, Wei Hou |
| المصدر: | PeerJ, Vol 11, p e14740 (2023) |
| بيانات النشر: | PeerJ Inc., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | IFIH1, DHX58, Hepatitis C, Polymorphism, Chronicity, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20–1.95], P = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27–1.78], P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| العلاقة: | https://peerj.com/articles/14740.pdfTest; https://peerj.com/articles/14740Test/; https://doaj.org/toc/2167-8359Test |
| DOI: | 10.7717/peerj.14740 |
| الوصول الحر: | https://doaj.org/article/760a5192b40f4b23a5fcfb4b85771352Test |
| رقم الانضمام: | edsdoj.760a5192b40f4b23a5fcfb4b85771352 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.14740 |