دورية أكاديمية
Comparison of gut microbiota between adults with autism spectrum disorder and obese adults
| العنوان: | Comparison of gut microbiota between adults with autism spectrum disorder and obese adults |
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| المؤلفون: | Qiang Zhang, Rong Zou, Min Guo, Mengmeng Duan, Quan Li, Huajun Zheng |
| المصدر: | PeerJ, Vol 9, p e10946 (2021) |
| بيانات النشر: | PeerJ Inc., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Autism spectrum disorder, Obesity, Gut microbiota, Adult autism spectrum disorder, 16S rRNA, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Background Autism spectrum disorder (ASD) and obesity are serious global public health problems. Studies have shown that ASD children are at a higher risk of obesity than the general population. To investigate the gut microbe characteristics of adults ASD and obese adults, we compared the gut microbiota of adults with ASD to obese adults. Methods The fecal samples were collected from 21 adult patients with ASD and 21 obese adults, and V3–V4 regions of 16S rRNA genes were sequenced by high-throughput DNA sequencing. The gut microbiota of adults with ASD and obese adults was compared. Results We observed the proportion of Firmicutes/Bacteroidetes in ASD was significantly increased, with families Lachnospiraceae and Ruminococcaceae significantly enriched in adult ASD. Eighteen genera, including Lachnospiracea incertae sedis, Ruminococcus, Blautia, and Holdemanella were significantly increased in adult ASD, whereas Megamonas and Fusobacterium were significantly increased in obesity. At the species level, we found six species enriched in ASD and three species enriched in obesity, including Phascolarctobacterium succinatuten producing propionate. Dialister succinatiphilus may be as a biomarker for predicting obesity, as well as Prevotella copri may be a common-owned pathogens of ASD and obesity. Conclusions Some conflicting results have been reported in microbiota studies of ASD, which may be related to age and obesity. Thus, the body mass index should be evaluated before analyzing the gut microbiota of patients with ASD, as obesity is prevalent in these individuals and gut microbiota is severally affected by obesity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| العلاقة: | https://peerj.com/articles/10946.pdfTest; https://peerj.com/articles/10946Test/; https://doaj.org/toc/2167-8359Test |
| DOI: | 10.7717/peerj.10946 |
| الوصول الحر: | https://doaj.org/article/c98ebdb8be834cd597a26ddfc820ccb9Test |
| رقم الانضمام: | edsdoj.98ebdb8be834cd597a26ddfc820ccb9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.10946 |