Diversity analysis of gut microbiota in osteoporosis and osteopenia patients
| العنوان: | Diversity analysis of gut microbiota in osteoporosis and osteopenia patients |
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| المؤلفون: | Wenjie Gao, Dingjun Hao, Yanhong Ji, Biao Wang, Yuhong Zeng, He-Ping Zhao, Yangyang Wang, Jihan Wang |
| المصدر: | PeerJ, Vol 5, p e3450 (2017) PeerJ |
| بيانات النشر: | PeerJ Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Firmicutes, lcsh:Medicine, Gut microbiota, Gut flora, Microbiology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Rheumatology, medicine, Bone mineral density, Gemmatimonadetes, biology, General Neuroscience, lcsh:R, Bacteroidetes, General Medicine, Diversity analysis, biology.organism_classification, Parabacteroides, medicine.disease, Osteopenia, Orthopedics, 030104 developmental biology, Osteoporosis, Proteobacteria, General Agricultural and Biological Sciences, Ruminococcaceae, 16S ribosomal RNA |
| الوصف: | Some evidence suggests that bone health can be regulated by gut microbiota. To better understand this, we performed 16S ribosomal RNA sequencing to analyze the intestinal microbial diversity in primary osteoporosis (OP) patients, osteopenia (ON) patients and normal controls (NC). We observed an inverse correlation between the number of bacterial taxa and the value of bone mineral density. The diversity estimators in the OP and ON groups were increased compared with those in the NC group. Beta diversity analyses based on hierarchical clustering and principal coordinate analysis (PCoA) could discriminate the NC samples from OP and ON samples. Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria constituted the four dominant phyla in all samples. Proportion of Firmicutes was significantly higher and Bacteroidetes was significantly lower in OP samples than that in NC samples (p p p |
| اللغة: | English |
| تدمد: | 2167-8359 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491d70ae555d06b353f1be32c3321ab6Test https://peerj.com/articles/3450Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....491d70ae555d06b353f1be32c3321ab6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21678359 |
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