دورية أكاديمية
Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging
| العنوان: | Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging |
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| المؤلفون: | Lee, Sulggi A., Sinclair, Elizabeth, Hatano, Hiroyu, Hsue, Priscilla Y., Epling, Lorrie, Hecht, Frederick M., Bangsberg, David, Martin, Jeffrey N., McCune, Joseph M., Deeks, Steven G., Hunt, Peter |
| المصدر: | OHSU-PSU School of Public Health Faculty Publications and Presentations |
| بيانات النشر: | PDXScholar |
| سنة النشر: | 2014 |
| المجموعة: | Portland State University: PDXScholar |
| مصطلحات موضوعية: | Cytomegalovirus infections, AIDS (Disease) -- Effect on T cell expression, AIDS (Disease) -- Treatment, Immune System Diseases, Virus Diseases |
| الوصف: | Background: Chronic antigenic stimulation by cytomegalovirus (CMV) is thought to increase ‘‘immunosenesence’’ of aging, characterized by accumulation of terminally differentiated CD28- CD8+ T cells and increased CD57, a marker of proliferative history. Whether chronic HIV infection causes similar effects is currently unclear. Methods: We compared markers of CD8+ T cell differentiation (e.g., CD28, CD27, CCR7, CD45RA) and CD57 expression on CD28- CD8+ T cells in healthy HIV-uninfected adults with and without CMV infection and in both untreated and antiretroviral therapy (ART)-suppressed HIV-infected adults with asymptomatic CMV infection. Results: Compared to HIV-uninfected adults without CMV (n = 12), those with asymptomatic CMV infection (n = 31) had a higher proportion of CD28-CD8+ T cells expressing CD57 (P = 0.005). Older age was also associated with greater proportions of CD28-CD8+ T cells expressing CD57 (rho: 0.47, P = 0.007). In contrast, untreated HIV-infected CMV+ participants (n = 55) had much lower proportions of CD28- CD8+ cells expressing CD57 than HIV-uninfected CMV+ participants (P,0.0001) and were enriched for less well-differentiated CD28- transitional memory (TTR) CD8+ T cells (P,0.0001). Chronically HIV-infected adults maintaining ART-mediated viral suppression (n = 96) had higher proportions of CD28-CD8+ T cells expressing CD57 than untreated patients (P,0.0001), but continued to have significantly lower levels than HIV-uninfected controls (P = 0.001). Among 45 HIV-infected individuals initiating their first ART regimen, the proportion of CD28-CD8+ T cells expressing CD57 declined (P,0.0001), which correlated with a decline in percent of transitional memory CD8+ T cells, and appeared to be largely explained by a decline in CD28-CD57- CD8+ T cell counts rather than an expansion of CD28-CD57+ CD8+ T cell counts. Conclusions: Unlike CMV and aging, which are associated with terminal differentiation and proliferation of effector memory CD8+ T cells, HIV inhibits this process, expanding less ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://pdxscholar.library.pdx.edu/sph_facpub/17Test; https://pdxscholar.library.pdx.edu/context/sph_facpub/article/1016/viewcontent/impact_of_hiv_on_cd8.PDFTest |
| DOI: | 10.1371/journal.pone.0089444 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0089444Test https://pdxscholar.library.pdx.edu/sph_facpub/17Test https://pdxscholar.library.pdx.edu/context/sph_facpub/article/1016/viewcontent/impact_of_hiv_on_cd8.PDFTest |
| رقم الانضمام: | edsbas.B1F24ABE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0089444 |
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