We describe a Congolese case of OEIS complex: Omphalocele-Exstrophy of the Bladder-anal imperforation-spina bifida, rare congenital malformation complex. Its genetic and environmental factors are not well known. In our case, the fetus has been exposed to alcohol throughout the all pregnancy and the mother contracted a gonococcal infection during the two first trimesters of her pregnancy. Key words: Omphalocele, exstrophy of the bladder, anal imperforation, spina bifida, alcohol
