Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
| العنوان: | Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1) |
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| المؤلفون: | Martina Bettarelli, Stefano Gotti, Brigitta Bonaldo, Antonino Casile, Giancarlo Panzica, Marilena Marraudino |
| المصدر: | European Journal of Histochemistry, Vol 65, Iss s1 (2021) European Journal of Histochemistry : EJH |
| بيانات النشر: | PAGEPress Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Vasopressin, vasopressin, Endocrine Disruptors, GPER1, Receptors, G-Protein-Coupled, Three-Chamber Test, Pregnancy, Lactation, Biology (General), Behavior, Animal, BPA, Endocrine disrupting chemicals, BPA, Three-Chamber test, vasopressin, oxytocin, GPER1, paraventricular nucleus, suprachiasmatic nucleus, medicine.anatomical_structure, Receptors, Estrogen, Female, paraventricular nucleus, hormones, hormone substitutes, and hormone antagonists, medicine.drug, medicine.medical_specialty, endocrine system, Histology, medicine.drug_class, Vasopressins, QH301-705.5, Biophysics, Estrous Cycle, Biology, Article, Phenols, Internal medicine, oxytocin, medicine, Endocrine system, Animals, Benzhydryl Compounds, Social Behavior, Estrous cycle, urogenital system, suprachiasmatic nucleus, Cell Biology, medicine.disease, endocrine disrupting chemicals, Mice, Inbred C57BL, Endocrinology, Oxytocin, Estrogen, Hormone, Paraventricular Hypothalamic Nucleus |
| الوصف: | Bisphenol A (BPA), an organic synthetic compound found in some plastics and epoxy resins, is classified as an endocrine disrupting chemical. Exposure to BPA is especially dangerous if it occurs during specific “critical periods” of life, when organisms are more sensitive to hormonal changes (i.e., intrauterine, perinatal, juvenile or puberty periods). In this study, we focused on the effects of chronic exposure to BPA in adult female mice starting during pregnancy. Three months old C57BL/6J females were orally exposed to BPA or to vehicle (corn oil). The treatment (4 µg/kg body weight/day) started the day 0 of pregnancy and continued throughout pregnancy, lactation, and lasted for a total of 20 weeks. BPA-treated dams did not show differences in body weight or food intake, but they showed an altered estrous cycle compared to the controls. In order to evidence alterations in social and sociosexual behaviors, we performed the Three-Chamber test for sociability, and analyzed two hypothalamic circuits (well-known targets of endocrine disruption) particularly involved in the control of social behavior: the vasopressin and the oxytocin systems. The test revealed some alterations in the displaying of social behavior: BPA-treated dams have higher locomotor activity compared to the control dams, probably a signal of high level of anxiety. In addition, BPA-treated dams spent more time interacting with no-tester females than with no-tester males. In brain sections, we observed a decrease of vasopressin immunoreactivity (only in the paraventricular and suprachiasmatic nuclei) of BPA-treated females, while we did not find any alteration of the oxytocin system. In parallel, we have also observed, in the same hypothalamic nuclei, a significant reduction of the membrane estrogen receptor GPER1 expression. |
| اللغة: | English |
| تدمد: | 2038-8306 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0b132dd52a8c7f64bc22cb503b7dfTest https://www.ejh.it/index.php/ejh/article/view/3272Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....63c0b132dd52a8c7f64bc22cb503b7df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20388306 |
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