التفاصيل البيبلوغرافية
| العنوان: |
The Relationship Between Serum Klotho Protein Levels and Risk of Hypertension. |
| المؤلفون: |
Yi-ting Zhou, Qing Xue, Hao Peng, Zheng-bao Zhu, Qian Xu, Qiu Zhang, Hong-mei Li |
| المصدر: |
American Journal of Hypertension; Jul2018, Vol. 31 Issue 7, p854-854, 1p |
| مصطلحات موضوعية: |
HYPERTENSION, BLOOD proteins, LOGISTIC regression analysis, BODY mass index, BLOOD sugar |
| مستخلص: |
Objective: To examine the relationship between serum Klotho protein levels and risk of hypertension in adults. Methods: A cross-sectional study was conducted in Jinchang district of Suzhou city from January to May 2010 in which 197 hypertensives and 197 normotensives were selected as research subjects using a 1:1 matched case-control study, and serum Klotho level was tested. The subjects were divided into 4 groups based on the quartile level of Klotho protein (<206, 206-290, 209-430, >430 ng/l) and the relationship between serum Klotho protein level and hypertension was analyzed by conditional Logistic regression analysis. Results: Of 197 pairs of subjects, 60 pairs were males and 137 pairs were females. The average age of all subjects was 51.7 ± 8.7 years old. The median serum Klotho protein level was 290 ng/l with the levels in hypertensives lower than in normotensives (270 vs. 314 ng/l, P = 0.004). The univariate conditional Logistic regression showed that compared to subjects in highest quartile Klotho level group, subjects in the first, second, and third quartile Klotho level groups had higher risk for hypertension with corresponding odds ratios (ORs) (95% confidence interval [CI]) of 2.46 (1.40-4.31), 2.24 (1.24-4.02), and 1.98 (1.12-3.51), respectively. After adjustment of covariates including age, lifestyle, family history of hypertension, body mass index, fasting blood glucose, serum uric acid, lipid levels, and microalbumin, their ORs (95% CI) of hypertension were 2.01 (1.08-3.71), 2.29 (1.20-4.39), and 1.55 (0.82-2.92), respectively. Conclusion: Lower serum levels of Klotho protein are correlated with a higher risk of hypertension. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
