التفاصيل البيبلوغرافية
| العنوان: |
Neurological perspectives on voltage-gated sodium channels. |
| المؤلفون: |
Eijkelkamp, Niels, Linley, John E., Baker, Mark D., Minett, Michael S., Cregg, Roman, Werdehausen, Robert, Rugiero, François, Wood, John N. |
| المصدر: |
Brain: A Journal of Neurology; Sep2012, Vol. 135 Issue 9, p2585-2612, 28p |
| مصطلحات موضوعية: |
ELECTRIC potential, SODIUM channels, EPILEPSY, CHRONIC pain, TRANSGENIC mice |
| مستخلص: |
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors. [ABSTRACT FROM AUTHOR] |
|
Copyright of Brain: A Journal of Neurology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder