التفاصيل البيبلوغرافية
| العنوان: |
Nicotine Intake in Adult Pod E-cigarette Users: Impact of User and Device Characteristics. |
| المؤلفون: |
Giberson, Jeremy, Nardone, Natalie, Addo, Newton, Khan, Sameera, Jacob, Peyton, Benowitz, Neal, St.Helen, Gideon |
| المصدر: |
Nicotine & Tobacco Research; Aug2023, Vol. 25 Issue 8, p1489-1495, 7p |
| مصطلحات موضوعية: |
ELECTRONIC cigarettes, NICOTINE replacement therapy, NICOTINE, SMOKING, MINTS (Plants), BIVARIATE analysis |
| الشركة/الكيان: |
UNITED States. Food & Drug Administration |
| مستخلص: |
Introduction This study examined user behavior, e-cigarette dependence, and device characteristics on nicotine intake among users of pod-mod e-cigarettes. Aims and Methods In 2019–2020, people who use pod-mods in the San Francisco Bay Area completed questionnaires and provided a urine sample for analysis of total nicotine equivalents (TNE). The relationship between TNE and e-cigarette use, e-cigarette brands, e-liquid nicotine strength, e-cigarette dependence, and urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), as a measure of combustible cigarette exposure, were examined. Results Of 100 participants (64% male, 71% in the 18–34 age group, 45% white), 53 used JUUL primarily, 12 used Puff Bar primarily, and 35 used other brands, including Suorin; 48 participants reported current cigarette smoking. Participants most often reported use of e-liquid with 4.5%–6.0% nicotine (68%), fruit (35%), tobacco (28%), and menthol or mint flavors (26%), used e-cigarettes on 25.5 (SD = 6.3) days a month, 10.2 (SD = 14.2) times a day, and 40% used 1–2 pods/cartridges per week. In bivariate analysis, urinary TNE was higher with greater frequency (days used) and intensity (number of pods used) of e-cigarette use, e-cigarette dependence, and combustible cigarette use. In multivariable analysis, days of e-cigarette use in the last 30 days, number of pods used per week, and NNAL levels were significantly associated with TNE. There was no significant impact of e-liquid nicotine strength on TNE. Conclusions Nicotine intake among people who used pod-mod e-cigarettes increased with e-cigarette consumption and e-cigarette dependence, but not with e-liquid nicotine strength. Our findings may inform whether FDA adopts a nicotine standard for e-cigarettes. Implications The study examined how device and user characteristics influence nicotine intake among pod-mod e-cigarette users. Nicotine intake increased with frequency (days of e-cigarette use in past 30 days) intensity of use (number of pods used per day) and e-cigarette dependence but not with the flavor or nicotine concentration of the e-liquids. Regulation of nicotine concentration of e-liquids is unlikely to influence nicotine exposure among adult experienced pod-mod users. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
