التفاصيل البيبلوغرافية
| العنوان: |
BINOCh: binding inference from nucleosome occupancy changes. |
| المؤلفون: |
Meyer, Clifford A.1, He, Housheng H.1, Brown, Myles1, Liu, X. Shirley1 |
| المصدر: |
Bioinformatics. Jul2011, Vol. 27 Issue 13, p1867-1868. 2p. |
| مصطلحات موضوعية: |
*DNA, *BIOCHEMICAL variation, *BIOINFORMATICS, *TRANSCRIPTION factors, *BINDING sites, *HISTONES, *BIOLOGISTS, *COMPUTER software |
| مستخلص: |
Summary: Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy, while those in the vicinity of the binding site itself are displaced. Genome-wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer-related histone modifications such as H3K4me2. Here, we present a software package, BINOCh that allows biologists to use such data to infer the identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation.Availability: The BINOCh open source Python package is freely available at http://liulab.dfci.harvard.edu/BINOChTest under the FreeBSD license.Contact: cliff@jimmy.harvard.edu; xsliu@jimmy.harvard.eduSupplementary information: Supplementary data are available at Bioinformatics online. [ABSTRACT FROM AUTHOR] |
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