التفاصيل البيبلوغرافية
| العنوان: |
Validation of the Swedish Diabetes Re-Grouping Scheme in Adult-Onset Diabetes in China. |
| المؤلفون: |
Xia Li, Shuting Yang, Chuqing Cao, Xiang Yan, Lei Zheng, Lanbo Zheng, Jiarui Da, Xiaohan Tang, Linong Ji, Xilin Yang, Zhiguang Zhou, Li, Xia, Yang, Shuting, Cao, Chuqing, Yan, Xiang, Zheng, Lei, Zheng, Lanbo, Da, Jiarui, Tang, Xiaohan, Ji, Linong |
| المصدر: |
Journal of Clinical Endocrinology & Metabolism; Oct2020, Vol. 105 Issue 10, p1-10, 10p |
| مصطلحات موضوعية: |
INSULIN, GESTATIONAL diabetes, DIABETES, TYPE 1 diabetes, TYPE 2 diabetes, GLYCOSYLATED hemoglobin, AUTOANTIBODIES, RESEARCH, AGE distribution, CROSS-sectional method, RESEARCH methodology, BLOOD sugar, EVALUATION research, MEDICAL cooperation, ETHNOLOGY research, SEVERITY of illness index, COMPARATIVE studies, ENZYMES, BODY mass index, INSULIN resistance |
| مصطلحات جغرافية: |
SWEDEN, CHINA |
| مستخلص: |
Context: This study applied the Swedish novel data-driven classification in Chinese newly diagnosed diabetic patients and validated its adoptability.Objective: This study aimed to validate the practicality of the Swedish diabetes regrouping scheme in Chinese adults with newly diagnosed diabetes.Design: Patients were classified into 5 subgroups by K-means and Two-Step methods according to 6 clinical parameters.Setting: Ambulatory care.Patients: A cross-sectional survey of 15 772 patients with adult-onset newly diagnosed diabetes was conducted in China from April 2015 to October 2017.Intervention: None.Main Outcome Measures: Six parameters including glutamate decarboxylase antibodies (GADA), age of onset, body mass index (BMI), glycated hemoglobin A1c (HbA1c), homoeostatic model assessment 2 estimates of β-cell function (HOMA2-B) and insulin resistance (HOMA2-IR) were measured to calculate the patient subgroups.Results: Our patients clustered into 5 subgroups: 6.2% were in the severe autoimmune diabetes (SAID) subgroup, 24.8% were in the severe insulin-deficient diabetes (SIDD) subgroup, 16.6% were in the severe insulin-resistance diabetes (SIRD) subgroup, 21.6% were in the mild obesity-related diabetes (MOD) subgroup and 30.9% were in the mild age-related diabetes (MARD) subgroup. When compared with the Swedish population, the proportion of SIDD subgroup was higher. In general, Chinese patients had younger age, lower BMI, higher HbA1c, lower HOMA2-B and HOMA2-IR, and higher insulin use but lower metformin usage than the Swedish patients.Conclusion: The Swedish diabetes regrouping scheme is applicable to adult-onset diabetes in China, with a high proportion of patients with the severe insulin deficient diabetes. Further validations of long-term diabetes complications remain warranted in future studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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