التفاصيل البيبلوغرافية
| العنوان: |
Glycemic modulation in neuro-oncology: experience and future directions using a modified Atkins diet for high-grade brain tumors. |
| المؤلفون: |
Strowd, Roy E., Cervenka, Mackenzie C., Henry, Bobbie J., Kossoff, Eric H., Hartman, Adam L., Blakeley, Jaishri O. |
| المصدر: |
Neuro-Oncology Practice; Sep2015, Vol. 2 Issue 3, p127-136, 10p |
| مصطلحات موضوعية: |
THERAPEUTICS, GLYCEMIC index, NEUROLOGICAL disorders, ATKINS diet, LOW-carbohydrate diet, BRAIN tumors, KETOGENIC diet, GLIOMAS, PATIENTS |
| مستخلص: |
Dietary glycemic modulation through high-fat, low-carbohydrate diets, which induce a state of systemic ketosis and alter systemic metabolic signaling, have been incorporated into the clinical management of patients with neurological disease for more than a century. Mounting preclinical evidence supports the antitumor, proapoptotic, and antiangiogenic effects of disrupting glycolytic metabolism through dietary intervention. In recent years, interest in incorporating such novel therapeutic strategies in neuro-oncology has increased. To date, 3 published studies incorporating novel dietary therapies in oncology have been reported, including one phase I study in neuro-oncology, and have set the stage for further study in this field. In this article, we review the biochemical pathways, preclinical data, and early clinical translation of dietary interventions that modulate systemic glycolytic metabolism in the management of primary malignant brain tumors. We introduce the modified Atkins diet (MAD), a novel dietary alternative to the classic ketogenic diet, and discuss the critical issues facing future study. [ABSTRACT FROM AUTHOR] |
|
Copyright of Neuro-Oncology Practice is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder