التفاصيل البيبلوغرافية
| العنوان: |
Impact of gender differences on myocardial salvage and post-ischaemic left ventricular remodelling after primary coronary angioplasty: new insights from cardiovascular magnetic resonance. |
| المؤلفون: |
Canali, Emanuele, Masci, Pier, Bogaert, Jan, Bucciarelli Ducci, Chiara, Francone, Marco, Mcalindon, Elisa, Carbone, Iacopo, Lombardi, Massimo, Desmet, Walter, Janssens, Stefan, Agati, Luciano |
| المصدر: |
European Heart Journal - Cardiovascular Imaging; Nov2012, Vol. 13 Issue 11, p948-953, 6p |
| مصطلحات موضوعية: |
TRANSLUMINAL angioplasty, MYOCARDIAL infarction treatment, MAGNETIC resonance imaging, CHI-squared test, LONGITUDINAL method, MEDICAL cooperation, MULTIVARIATE analysis, MYOCARDIAL reperfusion, REGRESSION analysis, RESEARCH, SEX distribution, T-test (Statistics), U-statistics, VENTRICULAR remodeling, DATA analysis software, DESCRIPTIVE statistics |
| مصطلحات جغرافية: |
BELGIUM, UNITED Kingdom, ITALY |
| مستخلص: |
Aims There is conflicting evidence on the impact of gender on reperfusion after primary coronary angioplasty (PPCI), and on left ventricular (LV) remodelling (LVR). In a cohort of patients with reperfused ST elevation myocardial infarction (STEMI), gender-related differences on myocardial reperfusion, and sex-related differences on LVR were assessed by using a comprehensive cardiac magnetic resonance (CMR) approach. Methods and results In four tertiary referral centres, 283 (238 males and 45 females) consecutive STEMI patients, treated with PPCI within 12 h from symptoms onset underwent CMR 3 ± 2 days after STEMI and at 4-month follow-up. By CMR, the area at risk, infarct size (IS), microvascular obstruction (MVO), and myocardial salvage index (MSI) were assessed. Women were older than men (P = 0.014), more hypertensive (P < 0.001) and more frequently presented with pre-infarct angina (P = 0.018). An MSI extent was significantly higher (P = 0.013), IS was significantly smaller at both time points (acute P < 0.001, follow-up P < 0.001), and the MVO extent was significantly smaller (P < 0.001) in women. At multivariate analysis, Killip class and female sex were independently associated with a higher MSI (P = 0.02, P = 0.05, respectively). A similar incidence of LVR in both sexes was observed at follow-up (P = 0.808). Conclusions The better reperfusion pattern observed in women by CMR in our population of reperfused STEMI suggests sex-based differences exist. No gender differences were observed with respect to incidence of LV remodelling at the follow-up mainly occurring in the subset of patients with a larger IS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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