التفاصيل البيبلوغرافية
| العنوان: |
Improvement in A1c Levels in Early Adulthood in the T1D Exchange: Impact of Racial, Socioeconomic, and Clinical Factors. |
| المؤلفون: |
Toschi, Elena, Bailey, Ryan J., Miller, Kellee M., Calhoun, Peter M. |
| المصدر: |
Journal of Clinical Endocrinology & Metabolism; May2021, Vol. 106 Issue 5, p1294-1302, 9p |
| مصطلحات موضوعية: |
ETHNICITY, YOUNG adults, ADULTS, BLOOD sugar monitoring, POPULATION, RESEARCH, INFORMATION services, RESEARCH methodology, TYPE 1 diabetes, RETROSPECTIVE studies, PROGNOSIS, COMMUNITY health services, MEDICAL cooperation, EVALUATION research, SOCIOECONOMIC factors, COMPARATIVE studies, IMPACT of Event Scale |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
Context: Glycemic control in adolescents with type 1 diabetes is poor; yet, it typically improves during early adulthood. Factors related to improvement of glycemic control are unclear.Objective: This work examines how demographic and clinical variables may affect trajectories of glycemic control over time.Methods: This retrospective, observational study comprised 1775 participants ages 18 to 30 years at enrollment in the T1D Exchange clinic registry. Latent class trajectory modeling was used to determine subgroups following a similar glycated hemoglobin A1c (HbA1c) trajectory over time.Results: Five distinct trajectories of HbA1c classes were identified: "low-decline" and "moderate-decline" groups had low or moderate HbA1c with a gradual decline, the "high-stable" group had high HbA1c and remained stable, and the "very high-rapid decline" and "very high-slow decline" groups had very high HbA1c with rapid or gradual decline. Compared with the "high-stable" group, the "low-decline" and "moderate-decline" groups were more likely to be male (P = .009), White non-Hispanic (P = .02), nonsmokers (P < .001), check self-monitoring blood glucose (SMBG) more frequently (P < .001), and have higher education (P < .001), lower body mass index (P = .02), and lower daily insulin dose (P < .001). Compared with the "very high-rapid decline" and "very high-slow decline" groups, the "low-decline" and "moderate-decline" groups were more likely to be male (P = .02), have higher education (P < .001), use insulin pumps (P = .01), be nonsmokers (P < .001), and have a higher number of SMBG checks per day at enrollment (P < .001).Conclusion: We determined 5 distinct patterns of glycemic control from early adulthood into adulthood. Further evaluation into the modifiable factors associated with a declining HbA1c trajectory would aid in the development of targeted interventions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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