التفاصيل البيبلوغرافية
| العنوان: |
Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus |
| المؤلفون: |
McGettrick, Padraig, Tinago, Willard, O’Brien, Julie, Miles, Sarah, Lawler, Leo, Garcia-Leon, Alejandro, Mahon, Niall, Lambert, John, Sheehan, Gerard, Landay, Alan, Sabin, Caroline A, Cotter, Aoife G, Mallon, Patrick W G, McGettrick, P, Alvarez Barco, E, Tinago, W, Garcia-Leon, A, McDermott, A, McGinty, T, Cotter, A G, Macken, A, Mallon, P W G, Kavanagh, E, McCarthy, G, Sheehan, G, Lambert, J, Powderly, W, Compston, J, Sabin, C, Cotter, A, Muldoon, E, Lambert, J S, Green, S, Leamy, K, Kenny, G, McCann, K, McCann, R, O’Broin, C, Waqas, S, Savinelli, S, Feeney, E, Garcia Leon, A, Miles, S, Alalwan, D, Negi, R, de Barra, E, McConkey, S |
| المساهمون: |
Irish Health Research Board |
| المصدر: |
The Journal of Infectious Diseases ; ISSN 0022-1899 1537-6613 |
| بيانات النشر: |
Oxford University Press (OUP) |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Infectious Diseases, Immunology and Allergy |
| الوصف: |
Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1093/infdis/jiae007 |
| DOI: |
10.1093/infdis/jiae007/56717621/jiae007.pdf |
| الإتاحة: |
https://doi.org/10.1093/infdis/jiae007Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.9A70362C |
| قاعدة البيانات: |
BASE |
