Impact of the factors shaping gut microbiota on obesity
| العنوان: | Impact of the factors shaping gut microbiota on obesity |
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| المؤلفون: | Saadullah Khattak, Xin-Ying Ji, Shaofeng Duan, Nazeer Hussain Khan, Yasmeen Ahmed Saleheldin Hassan Helmy, Ebenezeri Erasto Ngowi, Yi-Zhen Wang, Salma Sayed Mohamed Mahmoud, Dongdong Wu, Tao Li, Qi-Ying Jiang |
| المصدر: | Journal of Applied Microbiology. 131:2131-2147 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Dietary Fiber, Disease, Overweight, Gut flora, Weight Gain, Bioinformatics, Applied Microbiology and Biotechnology, 03 medical and health sciences, Pregnancy, Weight loss, Diabetes mellitus, medicine, Humans, Obesity, Microbiome, Risk factor, 030304 developmental biology, 0303 health sciences, Bacteria, biology, 030306 microbiology, General Medicine, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, Female, medicine.symptom, Biotechnology |
| الوصف: | Obesity is considered as a risk factor for chronic health diseases such as heart diseases, cancer, and diabetes 2. Reduced physical activities, lifestyle, poor nutritional diet, and genetics are among the risk factors associated with the development of obesity. In recent years, several studies have explored the link between the gut microbiome and the progression of diseases including obesity, with the shift in microbiome abundance and composition being the main focus. The alteration of gut microbiome composition affects both nutrients metabolism and specific gene expressions thereby disturbing body physiology. Specifically, the abundance of fiber-metabolizing microbes is associated with weight loss and that of protein and fat-metabolizing bacteria with weight gain. Various internal and external factors such as genetics, maternal obesity, mode of delivery, breastfeeding, nutrition, antibiotic use, and the chemical compounds present in the environment are known to interfere with the richness of the gut microbiota (GM), thereby influencing weight gain/loss and ultimately the development of obesity. However, the effectiveness of each factor in potentiating the shift in microbes' abundance to result in significant changes that can lead to obesity is not yet clear. In this review, we will highlight the factors involved in shaping gut microbiota, their influence on obesity and possible interventions. Understanding the influence of these factors on the diversity of the GM and how to improve their effectiveness on disease conditions could be key in the treatment of metabolic diseases. |
| تدمد: | 1365-2672 1364-5072 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8733fa1e98d1124c712d36aa1e832604Test https://doi.org/10.1111/jam.15036Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8733fa1e98d1124c712d36aa1e832604 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652672 13645072 |
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