Clinical features and prognosis of nocardiosis in patients with connective tissue diseases
| العنوان: | Clinical features and prognosis of nocardiosis in patients with connective tissue diseases |
|---|---|
| المؤلفون: | Ayako Ohyama, Daiki Tabuchi, Toshihiko Terasaki, Izumi Kurata, Yuya Kondo, Hiroyuki Takahashi, Saori Abe, Takayuki Sumida, Isao Matsumoto, Toshiki Sugita, Masaru Shimizu, Shinya Hagiwara, Atsumu Osada, Taihei Nishiyama, Hiroto Tsuboi, Shota Okamoto, Fumika Honda, Mizuki Yagishita |
| المصدر: | Modern Rheumatology. 31:636-642 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Vasculitis, Pathology, medicine.medical_specialty, Nocardia Infections, Connective tissue, Arthritis, Rheumatoid, Rheumatology, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Humans, Lupus Erythematosus, Systemic, In patient, Retrospective Studies, biology, business.industry, Nocardiosis, Cutaneous lesion, Nocardia, Middle Aged, Prognosis, medicine.disease, biology.organism_classification, Connective tissue disease, Anti-Bacterial Agents, medicine.anatomical_structure, Female, business |
| الوصف: | To investigate the clinical features and prognosis of nocardiosis complicated by connective tissue diseases (CTDs).We examined patients with CTDs who were diagnosed with nocardiosis from October 2004 to 2019. We retrospectively investigated patient characteristics and therapeutic outcomes. We then performed a comparison between survivors and non-survivors.Fourteen patients were examined. Underlying CTDs were systemic lupus erythematosus (28.6%), vasculitis syndrome (28.6%), rheumatoid arthritis (21.4%), adult Still disease (14.3%) and dermatomyositis (7.1%). Infected organs were lung (85.7%), brain (42.9%), skin/cutaneous lesions (28.6%) and muscle (7.1%). Disseminated infections were seen in nine patients (64.3%). At the onset of nocardiosis, all patients were given prednisolone (23.2 ± 11.9 mg/day). Only two patients (14.3%) were given TMP-SMX for prophylaxis of pneumocystis pneumonia. Relapse occurred in one patient (7.1%) and four patients (28.6%) died from nocardiosis for a cumulative survival rate at 52 weeks of 76.9%. In a comparison of survivors (71.4%) and non-survivors (28.6%), cutaneous lesions were significantly more frequent in the latter (10 vs 75%,Cutaneous lesions as a result of dissemination might be a risk factor for nocardiosis mortality in patients with CTDs. |
| تدمد: | 1439-7609 1439-7595 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dda6fcfccae877d109bdbcf23d0033Test https://doi.org/10.1080/14397595.2020.1823070Test |
| رقم الانضمام: | edsair.doi.dedup.....a5dda6fcfccae877d109bdbcf23d0033 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14397609 14397595 |
|---|