Potential of Hematopoietic Stem Cell Therapy in Hepatology: A Critical Review
| العنوان: | Potential of Hematopoietic Stem Cell Therapy in Hepatology: A Critical Review |
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| المؤلفون: | Philip N. Newsome, David J. Harrison, John N. Plevris, Steven Masson |
| المصدر: | STEM CELLS. 22:897-907 |
| بيانات النشر: | Oxford University Press (OUP), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Cell Transplantation, Cellular differentiation, Biology, Models, Biological, medicine, Macrophage fusion, Animals, Humans, Cell Lineage, Progenitor cell, Liver Diseases, Stem Cells, Regeneration (biology), Transdifferentiation, Gastroenterology, Hematopoietic stem cell, Cell Differentiation, Cell Biology, Hematopoietic Stem Cells, Liver Regeneration, Disease Models, Animal, medicine.anatomical_structure, Immunology, Hepatocytes, Molecular Medicine, Stem cell, Neuroscience, Developmental Biology, Adult stem cell |
| الوصف: | Adult stem cell plasticity raised expectations regarding novel cellular therapies of regenerative medicine after findings of unexpected plasticity were reported. In this review, reports of hematopoietic stem cells (HSCs) contributing to hepatocytic lineages are critically discussed with reference to rodent and human models. In particular, the role of liver injury and the potential contribution HSCs make to hepatic regeneration in both injury and physiological maintenance is reviewed. The relative contributions of genomic plasticity and cell fusion are studied across different model systems, highlighting possible factors that may explain differences between often conflicting reports. Insights from experimental studies will be described that shed light on the mechanisms underlying the migration, engraftment, and transdifferentiation of HSCs in liver injury. Although it appears that under differing circumstances, macrophage fusion, HSC fusion, and HSC transdifferentiation can all contribute to hepatic epithelial lineages, a much greater understanding of the factors that regulate the long-term efficacy of such cells is needed before this phenomenon can be used clinically. |
| تدمد: | 1549-4918 1066-5099 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36178a812b87881f07840133061cbf37Test https://doi.org/10.1634/stemcells.22-6-897Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36178a812b87881f07840133061cbf37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15494918 10665099 |
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