دورية أكاديمية
Leucocyte-derived micro-RNAs as candidate biomarkers in Brugada syndrome
| العنوان: | Leucocyte-derived micro-RNAs as candidate biomarkers in Brugada syndrome |
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| المؤلفون: | Steinberg, Christian, Gaudreault, Nathalie, Papadakis, Andreas I, Henry, Cyndi, Champagne, Jean, Philippon, François, O’Hara, Gilles, Blier, Louis, Plourde, Benoit, Nault, Isabelle, Roy, Karine, Sarrazin, Jean-François, Spatz, Alan, Bossé, Yohan |
| المساهمون: | IUCPQ-UL, Fonds de Recherche du Québec-Santé |
| المصدر: | Europace ; volume 25, issue 6 ; ISSN 1099-5129 1532-2092 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology (medical), Cardiology and Cardiovascular Medicine |
| الوصف: | Aims Risk stratification for sudden cardiac death in patients with Brugada syndrome remains a major challenge. Contemporary risk prediction models have only modest predictive value. The aim of this study was to assess the role of micro-RNAs from peripheral blood as candidate biomarkers in Brugada syndrome. Methods and results In this prospective study, Brugada patients and unaffected control individuals were enrolled for analysis of leucocyte-derived microRNAs (miRNAs) levels. Expression levels of 798 different circulating miRNAs were analysed on the NanoString® nCounter platform. All results were cross-validated by using a quantitative polymerase chain reaction. Micro-RNA expression levels of Brugada patients were compared with clinical data. A total of 21 definite Brugada patients (38% with a history of ventricular arrhythmia or cardiac arrest) and 30 unaffected control individuals were included in the study. Micro-RNA analysis showed a distinct expression profile in Brugada patients with 42 differentially expressed markers (38 up-regulated, 4 down-regulated miRNAs). The symptom status of Brugada patients was associated with a distinct miRNA signature. Micro-RNAs 145-5p and 585-3p were significantly up-regulated in symptomatic Brugada patients (P = 0.04). Incorporating miRNAs 145-5p and 585-3p into a multivariable model demonstrated significantly increased symptom prediction (area under the curve = 0.96; 95% confidence interval: 0.88–1.00). Conclusion Brugada patients display a distinct miRNA expression profile compared with unaffected control individuals. There is also evidence that certain miRNAs (miR-145-5p and miR-585-3p) are associated with the symptom status of Brugada patients. The results suggest the principal utility of leucocyte-derived miRNAs as prognostic biomarkers for Brugada syndrome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/europace/euad145 |
| الإتاحة: | https://doi.org/10.1093/europace/euad145Test https://academic.oup.com/europace/article-pdf/25/6/euad145/50595379/euad145.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.9E46CA87 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/europace/euad145 |
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