المؤلفون: Ferreira, David, Ludes, Pierre-Olivier, Diemunsch, Pierre, Noll, Eric, Torp, K. D., Meyer, Nicolas

المساهمون: Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA)

المصدر: ISSN: 0007-0912.

مصطلحات موضوعية: [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV]

العلاقة: hal-03797833; https://hal.science/hal-03797833Test; https://hal.science/hal-03797833/documentTest; https://hal.science/hal-03797833/file/S0007091220307960.pdfTest; PII: S0007-0912(20)30796-0

الإتاحة: https://doi.org/10.1016/j.bja.2020.08.062Test
https://hal.science/hal-03797833Test
https://hal.science/hal-03797833/documentTest
https://hal.science/hal-03797833/file/S0007091220307960.pdfTest

المؤلفون: Kaeuffer, Charlotte, Ruch, Yvon, Fabacher, Thibaut, Hinschberger, Olivier, Mootien, Joy, Eyriey, Magali, Greigert, Valentin, Gravier, Simon, Jocelyn, André, Dervieux, Benjamin, Pointurier, Valentin, Clere-Jehl, Raphael, Collange, Olivier, Ludes, Pierre-Olivier, Harlay, Marie-Line, Bilbaut, Pascal, Terrade, Jean Édouard, Felten, Renaud, Andrès, Emmanuel, Dieudonne, Yannick, Lescuyer, Sylvain, Ederlé, Carole, Perrin, Peggy, Curtiaud, Anais, De Marcillac, Fanny, Schmitt, Elise, Weill, François, Nisand, Gabriel, Le Hyaric, Coralie, Zhu, Yves-Jean, Hugerot, Antonin, Zecchi, Adrien, Maitrepierre, Flavie, Risser, Clémence, Goetsch, Thibaut, Du Sablon, Noémie Leclerc, Ehret, Marion, Vinee, Frederic, Bernard, Myriam, Koch, Clémence, Waegell, Arnaud, Dormegny, Léa, Meyer, Nicolas, Fafi-Kremer, Samira, Lefebvre, Nicolas, Hansmann, Yves, Martinot, Martin, Danion, François

المساهمون: Strasbourg University Hospital

المصدر: Open Forum Infectious Diseases ; volume 7, issue 10 ; ISSN 2328-8957

مصطلحات موضوعية: Infectious Diseases, Oncology

الوصف: We developed a score, with easily accessible data (age, sex, body mass index, dyspnea, inflammatory parameters), to predict the risk of rapid progression to severe coronavirus disease 2019. Using a cutoff of >6 points, the negative predictive value was 87%.

الإتاحة: https://doi.org/10.1093/ofid/ofaa405Test
http://academic.oup.com/ofid/article-pdf/7/10/ofaa405/34550918/ofaa405.pdfTest

المؤلفون: Arrigo, Mattia, Vodovar, Nicolas, Nougué, Hélène, Sadoune, Malha, Pemberton, Chris J, Ballan, Pamela, Ludes, Pierre-Olivier, Gendron, Nicolas, Carpentier, Alain, Cholley, Bernard, Bizouarn, Philippe, Cohen-Solal, Alain, Singh, Jagmeet P, Szymonifka, Jackie, Latremouille, Christian, Samuel, Jane-Lise, Launay, Jean-Marie, Pottecher, Julien, Richards, A Mark, Truong, Quynh A, Smadja, David M, Mebazaa, Alexandre

المساهمون: NIH

المصدر: European Heart Journal ; volume 39, issue 20, page 1794-1798 ; ISSN 0195-668X 1522-9645

الوصف: Aims Heart failure (HF) is accompanied by major neuroendocrine changes including the activation of the natriuretic peptide (NP) pathway. Using the unique model of patients undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF. Methods and results Venous blood samples from two patients undergoing replacement of the failing ventricles with a total artificial heart were collected before implantation and weekly thereafter until post-operative week 6. The ventricular removal was associated with an immediate drop in circulating NPs, a nearly total disappearance of circulating glycosylated proBNP and furin activity and a marked decrease in sNEP. From post-operative week 1 onwards, NP concentrations remained overall unchanged. In contrast, partial recoveries in glycosylated proBNP, furin activity, and sNEP were observed. Furthermore, while in patients with preserved systolic function (n = 6), sNEP concentrations in the coronary sinus and systemic vessels were similar (all P > 0.05), in patients with reduced left-ventricular systolic function, sNEP concentration, and activity were ∼three-fold higher in coronary sinus compared to systemic vessels (n = 21, all P < 0.0001), while the trans-pulmonary gradient was neutral (n = 5, P = 1.0). Conclusion The heart plays a pivotal role as a regulator of the endocrine response in systolic dysfunction, not only by directly releasing NPs but also by contributing to circulating sNEP, which in turn determines the bioavailability of other numerous vasoactive peptides.

الإتاحة: https://doi.org/10.1093/eurheartj/ehx679Test
http://academic.oup.com/eurheartj/article-pdf/39/20/1794/31191106/ehx679.pdfTest

المؤلفون: Demumieux, François, Ludes, Pierre-Olivier, Diemunsch, Pierre, Bennett-Guerrero, Elliott, Lujic, Marko, Lefebvre, François, Noll, Eric

المساهمون: Stony Brook University SUNY (SBU), State University of New York (SUNY)

المصدر: ISSN: 0007-0912.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

العلاقة: hal-03490142; https://hal.archives-ouvertes.fr/hal-03490142Test; PII: S0007-0912(20)30167-7

الإتاحة: https://doi.org/10.1016/j.bja.2020.03.011Test
https://hal.archives-ouvertes.fr/hal-03490142Test