دورية أكاديمية
A quantitative evaluation of the histological type dependence of the programmed death-ligand 1 expression in non-small cell lung cancer including various adenocarcinoma subtypes: a cross-sectional study
| العنوان: | A quantitative evaluation of the histological type dependence of the programmed death-ligand 1 expression in non-small cell lung cancer including various adenocarcinoma subtypes: a cross-sectional study |
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| المؤلفون: | Kojima, Kensuke, Sakamoto, Tetsuki, Kasai, Takahiko, Atagi, Shinji, Yoon, Hyungeun |
| المصدر: | Japanese Journal of Clinical Oncology ; volume 52, issue 3, page 281-285 ; ISSN 1465-3621 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology, General Medicine |
| الوصف: | The association between non-small cell lung cancer histology and programmed death-ligand 1 expression remains controversial. We retrospectively analyzed histological dependence of the programmed death-ligand 1 expression by a multiple regression analysis of 356 non-small cell lung cancer patients. The programmed death-ligand 1 expression patterns of adenocarcinoma were consistent with a pathological predominant growth pattern as a reference to papillary adenocarcinoma: minimally invasive adenocarcinoma[partial regression coefficient (B), 0.17; 95% confidence interval, 0.05–0.59], lepidic adenocarcinoma (B, 0.46; 95% confidence interval, 0.23–0.90), acinar adenocarcinoma (B, 1.98; 95% confidence interval, 1.05–3.76) and solid adenocarcinoma (B, 5.11; 95% confidence interval, 2.20–11.9). In histology other than adenocarcinoma, the programmed death-ligand 1 expression tended to be high with poor differentiation: adenosquamous carcinoma (B, 4.17; 95% confidence interval, 1.05–16.6), squamous cell carcinoma (B, 4.32; 95% confidence interval, 2.45–7.62) and pleomorphic carcinoma (B, 13.0; 95% confidence interval, 4.43–38.2). We showed quantitatively that the programmed death-ligand 1 expression in non-small cell lung cancer tended to be clearly histology-dependent, with more poorly differentiated histology showing a higher expression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/jjco/hyab202 |
| الإتاحة: | https://doi.org/10.1093/jjco/hyab202Test https://academic.oup.com/jjco/article-pdf/52/3/281/42688137/hyab202.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.4EC2BFF2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jjco/hyab202 |
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