TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response
| العنوان: | TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response |
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| المؤلفون: | Myles Brown, X. Shirley Liu, Dian Li, Robert T. Manguso, Lin Yang, Kathleen B. Yates, Sarah Kim, Cheryl J Wong, Ravindra Uppaluri, Gordon J. Freeman, Shengqing Gu, Liye Zhou, Jingxin Fu, Yi Zhang, Zexian Zeng, Wubing Zhang, Boning Zhang, Yang Liu, Xiaoqing Wang, Nofal Ouardaoui |
| المصدر: | Nucleic Acids Research |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | AcademicSubjects/SCI00010, medicine.medical_treatment, Context (language use), Biology, computer.software_genre, Biomarkers, Pharmacological, Mice, Immune system, Neoplasms, Databases, Genetic, Tumor Microenvironment, Genetics, medicine, Animals, Humans, Database Issue, Database, Cancer, Immunotherapy, medicine.disease, Immune checkpoint, Transplantation, Disease Models, Animal, Cytokine, Cancer cell, computer, Software |
| الوصف: | Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical mouse strains. They are widely used tools for studying tumor immunity and immunotherapy response in the context of a fully functional murine immune system. Large volumes of syngeneic mouse tumor expression profiles under different immunotherapy treatments have been generated, although a lack of systematic collection and analysis makes data reuse challenging. We present Tumor Immune Syngeneic MOuse (TISMO), a database with an extensive collection of syngeneic mouse model profiles with interactive visualization features. TISMO contains 605 in vitro RNA-seq samples from 49 syngeneic cancer cell lines across 23 cancer types, of which 195 underwent cytokine treatment. TISMO also includes 1518 in vivo RNA-seq samples from 68 syngeneic mouse tumor models across 19 cancer types, of which 832 were from immune checkpoint blockade (ICB) studies. We manually annotated the sample metadata, such as cell line, mouse strain, transplantation site, treatment, and response status, and uniformly processed and quality-controlled the RNA-seq data. Besides data download, TISMO provides interactive web interfaces to investigate whether specific gene expression, pathway enrichment, or immune infiltration level is associated with differential immunotherapy response. TISMO is available at http://tismo.cistrome.orgTest. |
| تدمد: | 1362-4962 0305-1048 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea8aeb43a27f0459a683de4cd8b0224Test https://doi.org/10.1093/nar/gkab804Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dea8aeb43a27f0459a683de4cd8b0224 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 03051048 |
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