دورية أكاديمية
The functional neuroanatomy of emotion processing in frontotemporal dementias
| العنوان: | The functional neuroanatomy of emotion processing in frontotemporal dementias |
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| المؤلفون: | Marshall, Charles R, Hardy, Christopher J D, Russell, Lucy L, Bond, Rebecca L, Sivasathiaseelan, Harri, Greaves, Caroline, Moore, Katrina M, Agustus, Jennifer L, van Leeuwen, Janneke E P, Wastling, Stephen J, Rohrer, Jonathan D, Kilner, James M, Warren, Jason D |
| المساهمون: | Dementia Research Centre, Alzheimer’s Research UK, Brain Research Trust, Wolfson Foundation, Alzheimer’s Society, Leonard Wolfson Experimental Neurology Centre, Medical Research Council UK, NIHR, UCLH Biomedical Research Centre, Clinical Research Fellowship, Leonard Wolfson Experimental Neurology Centre, Bart’s Charity, Alzheimer’s Society, MRC Clinician Scientist |
| المصدر: | Brain ; volume 142, issue 9, page 2873-2887 ; ISSN 0006-8950 1460-2156 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| الوصف: | Impaired processing of emotional signals is a core feature of frontotemporal dementia syndromes, but the underlying neural mechanisms have proved challenging to characterize and measure. Progress in this field may depend on detecting functional changes in the working brain, and disentangling components of emotion processing that include sensory decoding, emotion categorization and emotional contagion. We addressed this using functional MRI of naturalistic, dynamic facial emotion processing with concurrent indices of autonomic arousal, in a cohort of patients representing all major frontotemporal dementia syndromes relative to healthy age-matched individuals. Seventeen patients with behavioural variant frontotemporal dementia [four female; mean (standard deviation) age 64.8 (6.8) years], 12 with semantic variant primary progressive aphasia [four female; 66.9 (7.0) years], nine with non-fluent variant primary progressive aphasia [five female; 67.4 (8.1) years] and 22 healthy controls [12 female; 68.6 (6.8) years] passively viewed videos of universal facial expressions during functional MRI acquisition, with simultaneous heart rate and pupillometric recordings; emotion identification accuracy was assessed in a post-scan behavioural task. Relative to healthy controls, patient groups showed significant impairments (analysis of variance models, all P < 0.05) of facial emotion identification (all syndromes) and cardiac (all syndromes) and pupillary (non-fluent variant only) reactivity. Group-level functional neuroanatomical changes were assessed using statistical parametric mapping, thresholded at P < 0.05 after correction for multiple comparisons over the whole brain or within pre-specified regions of interest. In response to viewing facial expressions, all participant groups showed comparable activation of primary visual cortex while patient groups showed differential hypo-activation of fusiform and posterior temporo-occipital junctional cortices. Bi-hemispheric, syndrome-specific activations ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/brain/awz204 |
| DOI: | 10.1093/brain/awz204/28953824/awz204.pdf |
| الإتاحة: | https://doi.org/10.1093/brain/awz204Test http://academic.oup.com/brain/article-pdf/142/9/2873/29222604/awz204.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.3364F420 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awz204 |
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