دورية أكاديمية
MO116: Vitamin C Nephrotoxicity in a COVID-19 Patient: A Case Report
| العنوان: | MO116: Vitamin C Nephrotoxicity in a COVID-19 Patient: A Case Report |
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| المؤلفون: | Lemee, Noémie, Chamley, Paul, Francois, Alexis, Guincestre, Thomas, Duval, Marion, Promerat, Aude, Lemoine, Cécile |
| المصدر: | Nephrology Dialysis Transplantation ; volume 37, issue Supplement_3 ; ISSN 0931-0509 1460-2385 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Transplantation, Nephrology |
| الوصف: | BACKGROUND AND AIMS During the time of the COVID-19 pandemic, multiple treatment options have been investigated, even though their efficacy and secondary effects remain insufficiently known. We report the case of a vitamin C induced oxalate nephropathy in a COVID-19 patient with preexisting chronic kidney disease (CKD) resulting in irreversible acute renal failure. Vitamin C, also known as ascorbic acid, has been used as an anti-inflammatory therapy for COVID-19, but review of the literature shows similar cases of acute kidney injury (AKI), raising concern. METHOD We report the case of a 73-year-old Caucasian woman admitted for hyperthermia and digestive disorders. She had recently started a first-line chemotherapy for multiple myeloma with partial response. She also displayed preexisting stage 4 CKD (eGFR 18.50 mL/min/1.73 m² using CKD-EPI) of unknown aetiology. She was tested positive for SARS-CoV2 by nasopharyngeal swab and soon transferred to the intensive care unit. She received intravenous corticosteroids using dexamethasone 6 g/24 h for 10 days and a piperacillin + tazobactam probabilistic antibiotherapy. She also received high doses (15 g/24 h) of vitamin C for three consecutive days. No monoclonal antibodies were prescribed due to a previous vaccination with a positive serology upon admission. Although the patient recovered from respiratory tract infection, her kidney function progressively deteriorated with serum creatinine levels rising up to 8.06 g/dL, leading to her admission in our nephrology department. The patient was initially treated with high doses of diuretics for anasarca and an abdominal CT excluded urinary tract obstruction with normal kidney size and aspect. Urinary analysis showed protein to creatinine (p/c) ratio of 1348 g/g, and presence of urinary light chains. Her monoclonal spike was measured at 2.3 g/L and her kappa/lambda fraction was 1.74. Intermittent haemodialysis was initiated, and a kidney biopsy was performed. RESULTS Histology revealed hundreds of intratubular ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ndt/gfac066.019 |
| الإتاحة: | https://doi.org/10.1093/ndt/gfac066.019Test https://academic.oup.com/ndt/article-pdf/37/Supplement_3/gfac066.019/43535070/gfac066_019.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.C7DEAAB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/gfac066.019 |
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