0592 Hybrid Closed Loop Insulin Delivery Systems Reduce Perceived Hypoglycemia During Sleep in Adults With Long-Standing Type 1 Diabetes and Hypoglycemia Unawareness
| العنوان: | 0592 Hybrid Closed Loop Insulin Delivery Systems Reduce Perceived Hypoglycemia During Sleep in Adults With Long-Standing Type 1 Diabetes and Hypoglycemia Unawareness |
|---|---|
| المؤلفون: | Austin Matus, Susan Kohl Malone, Anneliese Flatt, Amy Peleckis, Cornelia Dalton-Bakes, Michael Rickels, Namni Goel |
| المصدر: | Sleep. 45:A260-A260 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Physiology (medical), Neurology (clinical) |
| الوصف: | Introduction Sleep-associated hypoglycemia is a major concern for individuals with type 1 diabetes (T1D). Hybrid closed loop insulin delivery systems with continuous glucose monitoring (HCL-CGM) may reduce the perceived frequency, severity, and impact of sleep-associated hypoglycemia. This analysis assessed changes in perceived sleep-associated hypoglycemia in individuals with T1D at high risk for hypoglycemia after initiating HCL-CGM. Methods Seven adults (median age=53y) with long-standing T1D (median duration=41y) and hypoglycemia unawareness participated in an ongoing 18-month clinical trial assessing effectiveness of HCL-CGM. At baseline and every 6 months thereafter, participants completed the validated Hypoglycemia Awareness Questionnaire (HypoA-Q), a 33-item tool consisting of three subscales (impaired awareness, symptom level, and symptom frequency), and 16 conceptually distinct items, including six items that relate to the frequency, severity, and impact of sleep-associated hypoglycemia, each which is scored and assessed individually. Friedman Tests assessed changes in items over the 18-month interval and Kendall’s W determined effect sizes. Results HCL-CGM significantly reduced the reported frequency of the following questions: (a) “How often you have had a hypo during your sleep?” (χ2(3)=8.4, p0.05; moderate effect size, W=0.26)”; (e) “…and someone else gave you a glucagon injection?” (p>0.05; small effect size, W=0.14); and (f) “…where you stayed asleep and only later realized that you had been hypo?” (p>0.05; small effect size, W=0.19). Conclusion HCL-CGM improved various critical aspects of perceived sleep-associated hypoglycemic events in individuals most at-risk for hypoglycemia. Our results have important implications for self-care and patient treatment in this population. Support (If Any) NIH R01DK117488 (NG), R01DK091331 (MRR), K99NR017416 (SKM), and UL1TR001878 (University of Pennsylvania Center for Human Phenomic Science); NASA NNX14AN49G and 80NSSC20K0243 (NG); Pennsylvania Department of Health SAP 4100079750 (IL). |
| تدمد: | 1550-9109 0161-8105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::1b7f49f6f27e950e73dd303eaf9308d2Test https://doi.org/10.1093/sleep/zsac079.589Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........1b7f49f6f27e950e73dd303eaf9308d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509109 01618105 |
|---|