Binding of Dopamine D1 Receptor and Noradrenaline Transporter in Individuals with Autism Spectrum Disorder: A PET Study
| العنوان: | Binding of Dopamine D1 Receptor and Noradrenaline Transporter in Individuals with Autism Spectrum Disorder: A PET Study |
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| المؤلفون: | Nobumasa Kato, Hidehiko Takahashi, Keisuke Takahata, Motoaki Nakamura, Yuta Aoki, Yasuharu Yamamoto, Ryuichiro Hashimoto, Kiwamu Matsuoka, Manabu Kubota, Chie Seki, Junya Fujino, Haruhisa Ohta, Takashi Itahashi, Yuhei Takado, Kenji Tagai, Hitoshi Shimada, Ming-Rong Zhang, Tetsuya Suhara, Yasunori Sano, Makoto Higuchi, Shisei Tei |
| المصدر: | Cerebral Cortex. 30:6458-6468 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Autism-spectrum quotient, medicine.medical_specialty, Autism Spectrum Disorder, Cognitive Neuroscience, Thalamus, behavioral disciplines and activities, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Dopamine receptor D1, Dopamine, Internal medicine, mental disorders, medicine, Humans, Anterior cingulate cortex, 030304 developmental biology, Temporal cortex, 0303 health sciences, Norepinephrine Plasma Membrane Transport Proteins, business.industry, Receptors, Dopamine D1, Brain, medicine.disease, medicine.anatomical_structure, Endocrinology, Autism spectrum disorder, Positron-Emission Tomography, business, 030217 neurology & neurosurgery, Neurotypical, medicine.drug |
| الوصف: | Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few studies have examined these neurotransmissions in individuals with ASD in vivo. Here, we investigated DA D1 receptor (D1R) and noradrenaline transporter (NAT) binding in adults with ASD (n = 18) and neurotypical controls (n = 20) by utilizing two different PET radioligands, [11C]SCH23390 and (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences in DA D1R (striatum, anterior cingulate cortex, and temporal cortex) or NAT (thalamus and pons) binding. However, in the ASD group, there were significant negative correlations between DA D1R binding (striatum, anterior cingulate cortex and temporal cortex) and the “attention to detail” subscale score of the Autism Spectrum Quotient. Further, there was a significant positive correlation between DA D1R binding (temporal cortex) and emotion perception ability assessed by the neurocognitive battery. Associations of NAT binding with empathic abilities and executive function were found in controls, but were absent in the ASD group. Although a lack of significant group differences in binding might be partly due to the heterogeneity of ASD, our results indicate that central DA and NA function might play certain roles in the clinical characteristics of ASD. |
| تدمد: | 1460-2199 1047-3211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d39092b3347f52de48ad34eb827dadTest https://doi.org/10.1093/cercor/bhaa211Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....83d39092b3347f52de48ad34eb827dad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602199 10473211 |
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