24,25-Dihydroxyvitamin D3 and Vitamin D Status of Community-Dwelling Black and White Americans
| العنوان: | 24,25-Dihydroxyvitamin D3 and Vitamin D Status of Community-Dwelling Black and White Americans |
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| المؤلفون: | Camille E. Powe, Kathryn J. Lucchesi, Julia Wenger, Guillermo Ortiz, S. Ananth Karumanchi, Neil R. Powe, Pirianthini Suntharalingam, Ravi Thadhani, Michele K. Evans, Anders H. Berg, Alan B. Zonderman |
| المصدر: | Clinical Chemistry. 61:877-884 |
| بيانات النشر: | Oxford University Press (OUP), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, 24,25-Dihydroxyvitamin D 3, Metabolite, African descent, Clinical Biochemistry, Parathyroid hormone, Article, White People, vitamin D deficiency, chemistry.chemical_compound, Tandem Mass Spectrometry, Internal medicine, medicine, Vitamin D and neurology, Humans, In patient, Vitamin D, Extramural, business.industry, Biochemistry (medical), Reproducibility of Results, Racial group, Middle Aged, Vitamin D Deficiency, medicine.disease, Black or African American, Cross-Sectional Studies, Endocrinology, chemistry, Parathyroid Hormone, Female, business, Biomarkers |
| الوصف: | BACKGROUND 24,25-Dihydroxyvitamin D [24,25(OH)2D] is a metabolite of 25-hydroxyvitamin D (25D). Blacks frequently have low total 25D without manifestations of vitamin D deficiency, suggesting that total serum 25D may incorrectly reflect vitamin D status in different racial groups. The ratio of serum 24,25(OH)2D to 25D [vitamin D metabolite ratio (VMR)] represents a new candidate biomarker for vitamin D status. METHODS We measured 24,25(OH)2D3 and 25D3 by mass spectrometry in a random community cohort of black (n = 212) and white (n = 164) Americans to evaluate VMR as a marker for vitamin D status. We measured parathyroid hormone concentrations by immunoassay to compare VMR and 25D3 against a physiological indicator of vitamin D deficiency. RESULTS Serum 24,25(OH)2D3 strongly correlated with 25D3 in both black and white study participants (r = 0.90, P < 0.001 and r = 0.86, P < 0.001 respectively). Blacks had lower mean 25D3 than whites [17.0 (7.8) vs 27.5 (11.3) ng/mL; 42.4 (19.5) vs 68.6 (28.2) nmol/L, P < 0.001] and lower mean 24,25(OH)2D3 [2.1 (1.3) vs 3.6 (2.0) ng/mL; 5.1 (3.1) vs 8.7 (4.8) nmol/L, P < 0.001]. In contrast to total 25D3 concentrations, mean VMR values were similar in blacks and whites [11.9 (4.0) vs 12.5 (3.4), P = 0.16, respectively] and were negatively correlated with parathyroid hormone concentrations in both races (rs = −0.26, P < 0.001, and rs = −0.25, P < 0.001, respectively). CONCLUSIONS Our results provide further evidence that measurement of total 25D for assessment of vitamin D status in patients of African descent deserves reevaluation and suggest that alternative measures such as VMR should be considered. |
| تدمد: | 1530-8561 0009-9147 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93f344850f7eb2a2d0683cc7b1bc7c0Test https://doi.org/10.1373/clinchem.2015.240051Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f93f344850f7eb2a2d0683cc7b1bc7c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308561 00099147 |
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