المؤلفون: Chung, Ming Kei, House, John S, Akhtari, Farida S, Makris, Konstantinos C, Langston, Michael A, Islam, Khandaker Talat, Holmes, Philip, Chadeau-Hyam, Marc, Smirnov, Alex I, Du, Xiuxia, Thessen, Anne E, Cui, Yuxia, Zhang, Kai, Manrai, Arjun K, Motsinger-Reif, Alison, Patel, Chirag J, Adamu, Yau, Adebamowo, Clement, Akhtari, Farida, Argos, Maria, Arunachalam, Saravanan, Baumert, Brittney, Beglarian, Emily, Berger, Kimberly, Bhutani, Jessie, Bisson, William, Breton, Carrie, Cai, Lu, Chao, Mu-rong, Chatziioannou, Anastasia Chrysovalantou, Cheng, Qiwen, Clark, Robert, Cohen Hubal, Elaine, Conti, David, Cooke, Marcus, Costello, Elizabeth, Dierickx, Erin, Dolinoy, Dana, Engel, Lawrence, Gao, Peng, Gaulke, Christopher, Giebelhaus, Ryland T, Goodrich, Jesse, Grafanaki, Katerina

المساهمون: National Institute for Environmental Health Sciences, National Institute on Aging

المصدر: Exposome ; volume 4, issue 1 ; ISSN 2635-2265

الوصف: This paper explores the exposome concept and its role in elucidating the interplay between environmental exposures and human health. We introduce two key concepts critical for exposomics research. Firstly, we discuss the joint impact of genetics and environment on phenotypes, emphasizing the variance attributable to shared and nonshared environmental factors, underscoring the complexity of quantifying the exposome’s influence on health outcomes. Secondly, we introduce the importance of advanced data-driven methods in large cohort studies for exposomic measurements. Here, we introduce the exposome-wide association study (ExWAS), an approach designed for systematic discovery of relationships between phenotypes and various exposures, identifying significant associations while controlling for multiple comparisons. We advocate for the standardized use of the term “exposome-wide association study, ExWAS,” to facilitate clear communication and literature retrieval in this field. The paper aims to guide future health researchers in understanding and evaluating exposomic studies. Our discussion extends to emerging topics, such as FAIR Data Principles, biobanked healthcare datasets, and the functional exposome, outlining the future directions in exposomic research. This abstract provides a succinct overview of our comprehensive approach to understanding the complex dynamics of the exposome and its significant implications for human health.

الإتاحة: https://doi.org/10.1093/exposome/osae001Test
https://academic.oup.com/exposome/article-pdf/4/1/osae001/56644165/osae001.pdfTest

المؤلفون: Wright, Robert O, Makris, Konstantinos C, Natsiavas, Pantelis, Fennell, Timothy, Rushing, Blake R, Wilson, Ander, Adamu, Yau, Adar, Sara D, Adebamowo, Clement, Akhtari, Farida, Argos, Maria, Arunachalam, Saravanan, Baumert, Brittney, Beglarian, Emily, Berger, Kimberly, Bhutani, Jessie, Cai, Lu, Calafat, Antonia, Chao, Mu-Rong, Chatziioannou, Anastasia Chrysovalantou, Cheng, Qiwen, Chung, Ming Kei, Clark, Robert, Hubal, Elaine Cohen, Cooke, Marcus, Costello, Elizabeth, Cui, Yuxia, Dierickx, Erin, Dolinoy, Dana, Du, Xiuxia, Folle, Aline Duarte, Gao, Peng, Gaulke, Christopher, Giebelhaus, Ryland T, Goodrich, Jesse, Grafanaki, Katerina, Gullapalli, Rama, Habre, Rima, Hanson, Heidi, Harari, Homero, Hart, Jaime, He, Jingxuan, Holmes, Philip, Hood, Darryl B, House, John, Hu, Hui, Hu, Chiung-Wen

المساهمون: National Institute Of Environmental Health Sciences of the National Institutes of Health

المصدر: Exposome ; volume 4, issue 1 ; ISSN 2635-2265

الوصف: Data sharing requires cooperation from data generators (eg, epidemiologists, lab investigators) and data users (eg, epidemiologists, biostatisticians, computer scientists). Data generation and data use in human exposome studies require significant but different skill sets and are separated temporally in many cases. Sharing will require maintaining a history of data generation and a system to address the concerns of data generators around credit for conducting rigorous work (eg, authorship). Sharing also requires addressing the needs of data users to facilitate harmonization, searchability and QA/QC of data. We present these issues from the perspectives of data generators and data users and include the special case of real-world data (eg, electronic health records). We conclude with recommendations to address how to better promote data sharing in exposomics through authorship, cost recovery and addressing ethical issues.

الإتاحة: https://doi.org/10.1093/exposome/osae004Test
https://academic.oup.com/exposome/article-pdf/4/1/osae004/57335059/osae004.pdfTest

المؤلفون: Spiegelman, Donna, Lovato, Laura C, Khudyakov, Polyna, Wilkens, Trine L, Adebamowo, Clement A, Adebamowo, Sally N, Appel, Lawrence J, Beulens, Joline WJ, Coughlin, Janelle W, Dragsted, Lars Ove, Edenberg, Howard J, Eriksen, Jane N, Estruch, Ramon, Grobbee, Diederick E, Gulayin, Pablo E, Irazola, Vilma, Krystal, John H, Lazo, Mariana, Murray, Margaret M, Rimm, Eric B, Schrieks, Ilse C, Williamson, Jeff D, Mukamal, Kenneth J

المصدر: European Journal of Preventive Cardiology ; volume 27, issue 18, page 1967-1982 ; ISSN 2047-4881 2047-4873

الوصف: Background Observational studies have documented lower risks of coronary heart disease and diabetes among moderate alcohol consumers relative to abstainers, but only a randomized clinical trial can provide conclusive evidence for or against these associations. Aim The purpose of this study was to describe the rationale and design of the Moderate Alcohol and Cardiovascular Health Trial, aimed to assess the cardiometabolic effects of one alcoholic drink daily over an average of six years among adults 50 years or older. Methods This multicenter, parallel-arm randomized trial was designed to compare the effects of one standard serving (∼11–15 g) daily of a preferred alcoholic beverage to abstention. The trial aimed to enroll 7800 people at high risk of cardiovascular disease. The primary composite endpoint comprised time to the first occurrence of non-fatal myocardial infarction, non-fatal ischemic stroke, hospitalized angina, coronary/carotid revascularization, or total mortality. The trial was designed to provide >80% power to detect a 15% reduction in the risk of the primary outcome. Secondary outcomes included diabetes. Adverse effects of special interest included injuries, congestive heart failure, alcohol use disorders, and cancer. Results We describe the design, governance, masking issues, and data handling. In three months of field center activity until termination by the funder, the trial randomized 32 participants, successfully screened another 70, and identified ∼400 additional interested individuals. Conclusions We describe a feasible design for a long-term randomized trial of moderate alcohol consumption. Such a study will provide the highest level of evidence for the effects of moderate alcohol consumption on cardiovascular disease and diabetes, and will directly inform clinical and public health guidelines.

الإتاحة: https://doi.org/10.1177/2047487320912376Test
http://academic.oup.com/eurjpc/article-pdf/27/18/1967/36165496/eurjpc1967.pdfTest

المؤلفون: Owolabi, Mayowa O, Akpa, Onoja M, Made, Felix, Adebamowo, Sally N, Ojo, Akinlolu, Adu, Dwomoa, Motala, Ayesha A, Mayosi, Bongani M, Ovbiagele, Bruce, Adebamowo, Clement, Tayo, Bamidele, Rotimi, Charles, Akinyemi, Rufus, Gebregziabher, Mulugeta, Sarfo, Fred, Wahab, Kolawole W, Parekh, Rulan S, Engel, Mark E, Chisala, Chisala, Peprah, Emmanuel, Mensah, George, Wiley, Ken, Troyer, Jennifer, Ramsay, Michèle

المساهمون: CHAIR, NIH, National Institutes of Health, NHGRI, Wellcome Trust, Center for Research on Genomics and Global Health, CRGGH, NIDDK

المصدر: International Journal of Epidemiology ; volume 48, issue 2, page 366-367g ; ISSN 0300-5771 1464-3685

مصطلحات موضوعية: General Medicine, Epidemiology

الإتاحة: https://doi.org/10.1093/ije/dyy261Test
http://academic.oup.com/ije/article-pdf/48/2/366/28479630/dyy261.pdfTest

المؤلفون: Adebamowo, Sally N, Dareng, Eileen O, Famooto, Ayotunde O, Offiong, Richard, Olaniyan, Olayinka, Obende, Kayode, Adebayo, Amos, Ologun, Sanni, Alabi, Bunmi, Achara, Peter, Bakare, Rasheed A, Odutola, Michael, Olawande, Oluwatoyosi, Okuma, James, Odonye, George, Adebiyi, Ruxton, Dakum, Patrick, Adebamowo, Clement A

المساهمون: National Institutes of Health

المصدر: International Journal of Epidemiology ; volume 46, issue 6, page 1745-1745j ; ISSN 0300-5771 1464-3685

مصطلحات موضوعية: General Medicine, Epidemiology

الإتاحة: https://doi.org/10.1093/ije/dyx050Test
http://academic.oup.com/ije/article-pdf/46/6/1745/24171747/dyx050.pdfTest

المؤلفون: Huo, Dezheng, Feng, Ye, Haddad, Stephen, Zheng, Yonglan, Yao, Song, Han, Yoo-Jeong, Ogundiran, Temidayo O., Adebamowo, Clement, Ojengbede, Oladosu, Falusi, Adeyinka G., Zheng, Wei, Blot, William, Cai, Qiuyin, Signorello, Lisa, John, Esther M., Bernstein, Leslie, Hu, Jennifer J., Ziegler, Regina G., Nyante, Sarah, Bandera, Elisa V., Ingles, Sue A., Press, Michael F., Deming, Sandra L., Rodriguez-Gil, Jorge L., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Ruiz-Narváez, Edward A., Sucheston-Campbell, Lara E., Bensen, Jeannette T., Simon, Michael S., Hennis, Anselm, Nemesure, Barbara, Leske, M. Cristina, Ambs, Stefan, Chen, Lin S., Qian, Frank, Gamazon, Eric R., Lunetta, Kathryn L., Cox, Nancy J., Chanock, Stephen J., Kolonel, Laurence N., Olshan, Andrew F., Ambrosone, Christine B., Olopade, Olufunmilayo I., Palmer, Julie R., Haiman, Christopher A.

المصدر: Human Molecular Genetics ; page ddw305 ; ISSN 0964-6906 1460-2083

مصطلحات موضوعية: Genetics (clinical), Genetics, Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1093/hmg/ddw305Test
https://academic.oup.com/hmg/article/2525910/Genomewide-Association-Studies-in-Women-of-AfricanTest

المؤلفون: Feng, Ye, Stram, Daniel O., Rhie, Suhn Kyong, Millikan, Robert C., Ambrosone, Christine B., John, Esther M., Bernstein, Leslie, Zheng, Wei, Olshan, Andrew F., Hu, Jennifer J., Ziegler, Regina G., Nyante, Sarah, Bandera, Elisa V., Ingles, Sue A., Press, Michael F., Deming, Sandra L., Rodriguez-Gil, Jorge L., Palmer, Julie R., Olopade, Olufunmilayo I., Huo, Dezheng, Adebamowo, Clement A., Ogundiran, Temidayo, Chen, Gary K., Stram, Alex, Park, Karen, Rand, Kristin A., Chanock, Stephen J., Le Marchand, Loic, Kolonel, Laurence N., Conti, David V., Easton, Douglas, Henderson, Brian E., Haiman, Christopher A.

المصدر: Human Molecular Genetics ; volume 23, issue 20, page 5518-5526 ; ISSN 0964-6906 1460-2083

مصطلحات موضوعية: Genetics (clinical), Genetics, Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1093/hmg/ddu252Test

المؤلفون: Dillon, David G, Gurdasani, Deepti, Riha, Johanna, Ekoru, Kenneth, Asiki, Gershim, Mayanja, Billy N, Levitt, Naomi S, Crowther, Nigel J, Nyirenda, Moffat, Njelekela, Marina, Ramaiya, Kaushik, Nyan, Ousman, Adewole, Olanisun O, Anastos, Kathryn, Azzoni, Livio, Boom, W Henry, Compostella, Caterina, Dave, Joel A, Dawood, Halima, Erikstrup, Christian, Fourie, Carla M, Friis, Henrik, Kruger, Annamarie, Idoko, John A, Longenecker, Chris T, Mbondi, Suzanne, Mukaya, Japheth E, Mutimura, Eugene, Ndhlovu, Chiratidzo E, Praygod, George, Pefura Yone, Eric W, Pujades-Rodriguez, Mar, Range, Nyagosya, Sani, Mahmoud U, Schutte, Aletta E, Sliwa, Karen, Tien, Phyllis C, Vorster, Este H, Walsh, Corinna, Zinyama, Rutendo, Mashili, Fredirick, Sobngwi, Eugene, Adebamowo, Clement, Kamali, Anatoli, Seeley, Janet, Young, Elizabeth H, Smeeth, Liam, Motala, Ayesha A, Kaleebu, Pontiano, Sandhu, Manjinder S, African Partnership for Chronic Disease Research (APCDR)

الوصف: BACKGROUND: Sub-Saharan Africa (SSA) has the highest burden of HIV in the world and a rising prevalence of cardiometabolic disease; however, the interrelationship between HIV, antiretroviral therapy (ART) and cardiometabolic traits is not well described in SSA populations. METHODS: We conducted a systematic review and meta-analysis through MEDLINE and EMBASE (up to January 2012), as well as direct author contact. Eligible studies provided summary or individual-level data on one or more of the following traits in HIV+ and HIV-, or ART+ and ART- subgroups in SSA: body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TGs) and fasting blood glucose (FBG) or glycated hemoglobin (HbA1c). Information was synthesized under a random-effects model and the primary outcomes were the standardized mean differences (SMD) of the specified traits between subgroups of participants. RESULTS: Data were obtained from 49 published and 3 unpublished studies which reported on 29 755 individuals. HIV infection was associated with higher TGs [SMD, 0.26; 95% confidence interval (CI), 0.08 to 0.44] and lower HDL (SMD, -0.59; 95% CI, -0.86 to -0.31), BMI (SMD, -0.32; 95% CI, -0.45 to -0.18), SBP (SMD, -0.40; 95% CI, -0.55 to -0.25) and DBP (SMD, -0.34; 95% CI, -0.51 to -0.17). Among HIV+ individuals, ART use was associated with higher LDL (SMD, 0.43; 95% CI, 0.14 to 0.72) and HDL (SMD, 0.39; 95% CI, 0.11 to 0.66), and lower HbA1c (SMD, -0.34; 95% CI, -0.62 to -0.06). Fully adjusted estimates from analyses of individual participant data were consistent with meta-analysis of summary estimates for most traits. CONCLUSIONS: Broadly consistent with results from populations of European descent, these results suggest differences in cardiometabolic traits between HIV-infected and uninfected individuals in SSA, which might be modified by ART use. In a region with the highest burden of HIV, it will be important to clarify these findings to ...

وصف الملف: text

العلاقة: https://researchonline.lshtm.ac.uk/id/eprint/1462954/1/dyt198.pdfTest; Dillon, David G; Gurdasani, Deepti; Riha, Johanna; Ekoru, Kenneth; Asiki, Gershim; Mayanja, Billy N; Levitt, Naomi S; Crowther, Nigel J; Nyirenda, Moffat ; Njelekela, Marina; +41 more. Ramaiya, Kaushik; Nyan, Ousman; Adewole, Olanisun O; Anastos, Kathryn; Azzoni, Livio; Boom, W Henry; Compostella, Caterina; Dave, Joel A; Dawood, Halima; Erikstrup, Christian; Fourie, Carla M; Friis, Henrik; Kruger, Annamarie; Idoko, John A; Longenecker, Chris T; Mbondi, Suzanne; Mukaya, Japheth E; Mutimura, Eugene; Ndhlovu, Chiratidzo E; Praygod, George; Pefura Yone, Eric W; Pujades-Rodriguez, Mar; Range, Nyagosya; Sani, Mahmoud U; Schutte, Aletta E; Sliwa, Karen; Tien, Phyllis C; Vorster, Este H; Walsh, Corinna; Zinyama, Rutendo; Mashili, Fredirick; Sobngwi, Eugene; Adebamowo, Clement; Kamali, Anatoli; Seeley, Janet ; Young, Elizabeth H; Smeeth, Liam ; Motala, Ayesha A; Kaleebu, Pontiano ; Sandhu, Manjinder S; African Partnership for Chronic Disease Research (APCDR); (2013) Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis. International journal of epidemiology, 42 (6). pp. 1754-1771. ISSN 0300-5771 DOI: https://doi.org/10.1093/ije/dyt198Test

الإتاحة: https://doi.org/10.1093/ije/dyt198Test
https://researchonline.lshtm.ac.uk/id/eprint/1462954Test/
https://researchonline.lshtm.ac.uk/id/eprint/1462954/1/dyt198.pdfTest

المؤلفون: Doumatey, Ayo P., Chen, Guanjie, Tekola Ayele, Fasil, Zhou, Jie, Erdos, Michael, Shriner, Daniel, Huang, Hanxia, Adeleye, Jokotade, Balogun, Williams, Fasanmade, Olufemi, Johnson, Thomas, Oli, Johnnie, Okafor, Godfrey, Amoah, Albert, Eghan, Benjamin A., Agyenim-Boateng, Kofi, Acheampong, Joseph, Adebamowo, Clement, Gerry, Norman P., Christman, Michael F., Adeyemo, Adebowale, Rotimi, Charles N.

المصدر: Human Molecular Genetics ; volume 21, issue 13, page 3063-3072 ; ISSN 0964-6906 1460-2083

مصطلحات موضوعية: Genetics (clinical), Genetics, Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1093/hmg/dds133Test

المؤلفون: Huo, Dezheng, Zheng, Yonglan, Ogundiran, Temidayo O., Adebamowo, Clement, Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Simon, Michael S., John, Esther M., Hennis, Anselm, Nemesure, Barbara, Wu, Suh-Yuh, Leske, M.Cristina, Ambs, Stefan, Niu, Qun, Zhang, Jing, Cox, Nancy J., Olopade, Olufunmilayo I.

المصدر: Carcinogenesis ; volume 33, issue 4, page 835-840 ; ISSN 1460-2180 0143-3334

مصطلحات موضوعية: Cancer Research, General Medicine

الإتاحة: https://doi.org/10.1093/carcin/bgs093Test
http://academic.oup.com/carcin/article-pdf/33/4/835/17290929/bgs093.pdfTest