Public Health Considerations for the Introduction of New Rotavirus Vaccines for Infants: A Case Study of Tetravalent Rhesus Rotavirus-based Reassortant Vaccine
| العنوان: | Public Health Considerations for the Introduction of New Rotavirus Vaccines for Infants: A Case Study of Tetravalent Rhesus Rotavirus-based Reassortant Vaccine |
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| المؤلفون: | John D. Clemens, Abdollah Naficy, Roger I. Glass, Neysa Keckich, Malla Rao |
| المصدر: | Epidemiologic Reviews. 21:24-42 |
| بيانات النشر: | Oxford University Press (OUP), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Rotavirus, medicine.medical_specialty, Pediatrics, Epidemiology, viruses, Population, Vaccines, Attenuated, medicine.disease_cause, Rotavirus Infections, medicine, Animals, Humans, Intensive care medicine, education, Disease burden, education.field_of_study, business.industry, Public health, Vaccination, Rotavirus Vaccines, Infant, virus diseases, Viral Vaccines, General Medicine, Macaca mulatta, United States, Clinical trial, Diarrhea, Immunization, medicine.symptom, business |
| الوصف: | This paper discusses considerations in public health for the introduction of tetravalent rhesus rotavirus-based reassortant vaccine (RRV-TV) for infants. RRV-TV contains a mixture of G1, G2, and G4 reassortants with a parent strain of MMU 18006. Field trials were performed to evaluate the protective efficacy of RRV-TV in infants and to determine the efficacy of RRV-TV higher-dose regimen. The use of RRV-TV in infant immunization brings about the following relevant issues: 1) availability of alternative or complementary non-vaccine interventions; 2) burden of disease; 3) epidemiologic features of rotavirus disease; 4) protective characteristics of the vaccine in efficacy trials; 5) clinical effectiveness of the vaccine; and 6) balance between costs and benefits of vaccination. Moreover, due to its high cost, RRV-TV would not be a cost-saving public health tool in developing countries unless it is made affordable. An effective vaccine against rotavirus is needed due to the following factors: 1) immense burden of rotavirus; 2) persistence of disease burden despite the promotion of rehydration therapy for acute diarrheas in childhood; and 3) lack of effectiveness of nonvaccination approaches. |
| تدمد: | 1478-6729 0193-936X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5153e2ce8cc205ce2edffef30c498accTest https://doi.org/10.1093/oxfordjournals.epirev.a017986Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5153e2ce8cc205ce2edffef30c498acc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14786729 0193936X |
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