Trastuzumab-Related Cardiotoxicity in Early Breast Cancer: A Cohort Study
| العنوان: | Trastuzumab-Related Cardiotoxicity in Early Breast Cancer: A Cohort Study |
|---|---|
| المؤلفون: | Matteo Franchi, Lorenzo Moja, Eva Negri, G Corrao, Carlo La Vecchia, Martina Bonifazi, Marta Rossi, Alberto Zambelli, A Zambon, Carlo Zocchetti |
| المساهمون: | Bonifazi, M, Franchi, M, Rossi, M, Moja, L, Zambelli, A, Zambon, A, Corrao, G, La Vecchia, C, Zocchetti, C, Negri, E |
| المصدر: | The Oncologist. 18:795-801 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, Heart Diseases, Survival, Breast Neoplasms, Kaplan-Meier Estimate, Antibodies, Monoclonal, Humanized, Disease-Free Survival, Cohort Studies, Breast cancer, Trastuzumab, Internal medicine, Breast Cancer, medicine, Humans, skin and connective tissue diseases, Adverse effect, neoplasms, MED/01 - STATISTICA MEDICA, Aged, Neoplasm Staging, Cardiotoxicity, business.industry, Proportional hazards model, Incidence (epidemiology), Hazard ratio, Early breast cancer, Middle Aged, medicine.disease, Adjuvant chemotherapy, Surgery, Oncology, Female, business, medicine.drug, Cohort study |
| الوصف: | Background. Concerns have been raised about the cardiac safety profile of trastuzumab for the adjuvant treatment of early stage breast cancer in clinical practice. We assessed tras- tuzumab-related cardiotoxicity and its predictors in a large co-hort of Italian women. Methods. Through a record linkage between four regional health care databases, we identified the rate of severe car-diac adverse events among women treated with trastu-zumab for early breast cancer in Lombardy. The cumulative risk of cardiotoxicity was estimated using the Kaplan-Meier method, and independent predictors were assessed using the Cox model. Results. Of 2,046 trastuzumab users, 53 (2.6%) experienced at least one hospitalization for a cardiac event, and there were two cardiac deaths. The cumulative risk of cardiotoxicity in- creased up to 2 years after starting treatment, reaching a pla-teau at 2.8%. The risk was low (0.2%) among young women, whereas the incidence was approximately 10% in women aged >70 years, irrespective of cardiovascular risk factors. Age and history of cardiac disease were strong predictors of cardiotoxicity, with a hazard ratio of 11.3 (95% confidence in-terval [CI]: 3.5-36.6) for women aged >70 years as compared with those |
| تدمد: | 1549-490X 1083-7159 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92509903bcf5f0193104234266e46e8Test https://doi.org/10.1634/theoncologist.2013-0065Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c92509903bcf5f0193104234266e46e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1549490X 10837159 |
|---|