Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking
| العنوان: | Carbonic anhydrase IX is associated with early pulmonary spreading of primary colorectal carcinoma and tobacco smoking |
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| المؤلفون: | Emmanuella Guenova, Thomas Schweiger, György Lang, Denise Traxler, Dagmar Kollmann, Konrad Hoetzenecker, Christoph Nikolowsky, Hendrik Jan Ankersmit, Walter Klepetko, Peter Birner |
| المساهمون: | University of Zurich, Ankersmit, Hendrik Jan |
| المصدر: | European Journal of Cardio-Thoracic Surgery. 46:92-99 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Oncology, Pathology, Lung Neoplasms, Colorectal cancer, Metastasis, Nicotine, Phosphorylation, Carbonic Anhydrases, Smoking, 10177 Dermatology Clinic, General Medicine, Middle Aged, Prognosis, Ganglionic Stimulants, Immunohistochemistry, 2746 Surgery, medicine.anatomical_structure, Female, Metastasectomy, Colorectal Neoplasms, Cardiology and Cardiovascular Medicine, HT29 Cells, medicine.drug, Adult, STAT3 Transcription Factor, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, Antigens, Neoplasm, In vivo, Internal medicine, medicine, Humans, Carbonic Anhydrase IX, Aged, Retrospective Studies, Lung, business.industry, Carcinoma, Retrospective cohort study, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, 2740 Pulmonary and Respiratory Medicine, Surgery, business, Biomarkers |
| الوصف: | OBJECTIVES: Pulmonary metastasectomy is performed routinely in selected patients with metastatic spreading to the lungs. According to current guidelines, the tumour biology should be taken into account when selecting patients for a resection. Carbonic anhydrase IX (CA9) expression has been shown to be a common feature in primary tumour growth and metastasis and it negatively affects the clinical outcome in various malignancies. Data on CA9 in pulmonary metastases are lacking. METHODS: Forty-four patients with primary colorectal cancer (CRC) who underwent curative pulmonary metastasectomy were included in this study. We determined the expression of CA9 in pulmonary metastases and corresponding primaries by immunohistochemistry. The expression level was correlated with clinical parameters and patients’ smoking habits. Furthermore, the impact of nicotine treatment on phosphorylation of STAT3, HIF-1α and CA9 expression was assessed in HT29 cells. RESULTS: High expression of CA9 in resected pulmonary metastases and corresponding primary tumours correlated with early spreading to the lung (both P< 0.001). Moreover, CA9 expression was affected by the smoking habits of the patients. Treating HT29 cells with nicotine resulted in an induction of CA9 in vitro. This induction was associated with STAT3 phosphorylation and was independent of HIF-1α. CONCLUSIONS: This study provides first evidence of CA9 expression in pulmonary metastases of CRC and suggests a role of CA9 as a prognostic marker. Moreover, our in vitro and in vivo data indicate an association between tobacco smoking and CA9 expression. Immunohistochemical assessment of CA9 expression might serve as an additional tool in decision-making for selecting patients for pulmonary metastasectomy. |
| وصف الملف: | Schweiger_T_et_al._-_Eur_J_Cardiothorac_Surg_2013.pdf - application/pdf |
| تدمد: | 1873-734X 1010-7940 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2431b7f2e2b2e8c6e99dd1e2dd9156Test https://doi.org/10.1093/ejcts/ezt542Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea2431b7f2e2b2e8c6e99dd1e2dd9156 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1873734X 10107940 |
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