دورية أكاديمية
Molecular and translational advances in meningiomas
| العنوان: | Molecular and translational advances in meningiomas |
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| المؤلفون: | Suppiah S., Nassiri F., Bi W. L., Dunn I. F., Hanemann C. O., Horbinski C. M., Hashizume R., James C. D., Mawrin C., Noushmehr H., Perry A., Sahm F., Sloan A., Von Deimling A., Wen P. Y., Aldape K., Zadeh G., Au K., Barnhartz-Sloan J., Brastianos P. K., Butowski N., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Griffith B., Herold-Mende C., Huang R. Y., James D., Jenkinson M. D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mansouri A., McDermott M., Munoz D., Ng H. -K., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Deimling A. V., Walbert T., Westphal M., Workewych A. M. |
| المساهمون: | S. Suppiah, F. Nassiri, B. W. L., I.F. Dunn, C.O. Hanemann, C.M. Horbinski, R. Hashizume, C.D. Jame, C. Mawrin, H. Noushmehr, A. Perry, F. Sahm, A. Sloan, A. Von Deimling, P.Y. Wen, K. Aldape, G. Zadeh, K. Au, J. Barnhartz-Sloan, P.K. Brastiano, N. Butowski, C. Carlotti, M.D. Cusimano, F. Dimeco, K. Drummond, E. Galani, C. Giannini, R. Goldbrunner, B. Griffith, C. Herold-Mende, R.Y. Huang, D. Jame, M.D. Jenkinson, C. Jungk, T.J. Kaufman, B. Krischek, D. Lachance, C. Lafougere, I. Lee, J.C. Liu, Y. Mamatjan, A. Mansouri, M. Mcdermott, D. Munoz, N. H. -K., F. Pirouzmand, L.M. Poisson, B. Pollo, D. Raleigh, A. Saladino, T. Santariu, C. Schichor, D. Schultz, N.O. Schmidt, W. Selman, J. Spear, J. Snyder, G. Tabatabai, M. Tatagiba, D. Tirapelli, J.C. Tonn, D. Tsang, M.A. Vogelbaum, A.V. Deimling, T. Walbert, M. Westphal, A.M. Workewych |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2019 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | biomolecular, cell line, epigenetic, genetic, sporadic meningioma, xenograft, Settore MED/27 - Neurochirurgia |
| الوصف: | Meningiomas are the most common primary intracranial neoplasm. The current World Health Organization (WHO) classification categorizes meningiomas based on histopathological features, but emerging molecular data demonstrate the importance of genomic and epigenomic factors in the clinical behavior of these tumors. Treatment options for symptomatic meningiomas are limited to surgical resection where possible and adjuvant radiation therapy for tumors with concerning histopathological features or recurrent disease. At present, alternative adjuvant treatment options are not available in part due to limited historical biological analysis and clinical trial investigation on meningiomas. With advances in molecular and genomic techniques in the last decade, we have witnessed a surge of interest in understanding the genomic and epigenomic landscape of meningiomas. The field is now at the stage to adopt this molecular knowledge to refine meningioma classification and introduce molecular algorithms that can guide prediction and therapeutics for this tumor type. Animal models that recapitulate meningiomas faithfully are in critical need to test new therapeutics to facilitate rapid-cycle translation to clinical trials. Here we review the most up-to-date knowledge of molecular alterations that provide insight into meningioma behavior and are ready for application to clinical trial investigation, and highlight the landscape of available preclinical models in meningiomas. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30649490; info:eu-repo/semantics/altIdentifier/wos/WOS:000460635600003; volume:21; issue:Suppl 1; firstpage:4; lastpage:17; numberofpages:14; journal:NEURO-ONCOLOGY; http://hdl.handle.net/2434/653469Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060044130 |
| DOI: | 10.1093/neuonc/noy178 |
| الإتاحة: | https://doi.org/10.1093/neuonc/noy178Test http://hdl.handle.net/2434/653469Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3131D101 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/neuonc/noy178 |
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