دورية أكاديمية
Inflammatory Activation and Left Ventricular Mass in Essential Hypertension
| العنوان: | Inflammatory Activation and Left Ventricular Mass in Essential Hypertension |
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| المؤلفون: | Roselló-Lletí, Esther, Rivera, Miguel, Martínez-Dolz, Luís, González Juanatey, Jose R., Cortés, Raquel, Jordán, Alejandro, Morillas, Pedro, Lauwers, Catheline, Calabuig, Jose R., Antorrena, Isabel, de Rivas, Beatriz, Portolés, Manuel, Bertomeu, Vicente |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2009 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Article |
| الوصف: | Background Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients with essential hypertension (HT). Methods We studied 251 asymptomatic hypertensive patients (142 with LVH and 109 without LVH), referred from 11 hospitals. A routine physical examination, laboratory analyses, and echo-Doppler study were performed. Plasma soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and sTNF-R2), interleukin-6 (IL-6), and interleukin-1 receptor antagonist (IL-1ra) were centrally determined. Results Hypertensive patients with LVH had higher inflammatory cytokine levels than the group without hypertrophy ( P < 0.001). Multivariate linear regression reported that sTNF-R1 ( P < 0.01) was an independent predictor of left ventricular mass index (LVMI). All cytokines had significant area under the curves for detection of LVH, but sTNF-R1 has the highest area, 0.71 ± 0.03 ( P < 0.001). Finally, prevalence of LVH was increased in the group of patients with higher cytokine levels, and logistic regression analysis showed that sTNF-R1 (odds ratio = 2.59, 95% CI of 1.14–5.87) was an independent predictor of LVH. Conclusions Cytokine levels were significantly correlated with LVMI in hypertensive patients. The sTNF-R1 was an independent predictor of LVMI. Plasma sTNF-R1 concentrations could be a predictive factor of LVH in patients with essential HT. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://ajh.oxfordjournals.org/cgi/content/short/22/4/444Test; http://dx.doi.org/10.1038/ajh.2008.369Test |
| DOI: | 10.1038/ajh.2008.369 |
| الإتاحة: | https://doi.org/10.1038/ajh.2008.369Test http://ajh.oxfordjournals.org/cgi/content/short/22/4/444Test |
| حقوق: | Copyright (C) 2009, American Journal of Hypertension, Ltd. |
| رقم الانضمام: | edsbas.D677E3C6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ajh.2008.369 |
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