Achieving the HbA1c Target Requires Longer Time in Range in Pregnant Women With Type 1 Diabetes
| العنوان: | Achieving the HbA1c Target Requires Longer Time in Range in Pregnant Women With Type 1 Diabetes |
|---|---|
| المؤلفون: | Jianping Weng, Daizhi Yang, Ping Ling, Sihui Luo, Xueying Zheng, Jiajun Zhao, Qin Huang, Xinhua Xiao, Mei Zhang, Nan Gu, Ji Hu, Fang Liu, Jing Lu, Zhiguang Zhou, Jinhua Yan |
| المصدر: | The Journal of Clinical Endocrinology and Metabolism |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | HBA1c target, Adult, Blood Glucose, medicine.medical_specialty, China, Time Factors, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Pregnancy in Diabetics, Context (language use), Gestational Age, Glycemic Control, Biochemistry, chemistry.chemical_compound, Endocrinology, Pregnancy, Internal medicine, Diabetes mellitus, glycated hemoglobin A1c, Medicine, Humans, Online Only Articles, Clinical Research Articles, Glycemic, Glycated Hemoglobin, Type 1 diabetes, Continuous glucose monitoring, business.industry, Obstetrics, Blood Glucose Self-Monitoring, Biochemistry (medical), Postpartum Period, nutritional and metabolic diseases, medicine.disease, type 1, Diabetes Mellitus, Type 1, chemistry, time in range, diabetes mellitus, Female, Glycated hemoglobin, business, AcademicSubjects/MED00250 |
| الوصف: | ContextContinuous glucose monitoring (CGM) overcomes the limitations of glycated hemoglobin (HbA1c).ObjectiveThis study aimed to investigate the relationship between CGM metrics and laboratory HbA1c in pregnant women with type 1 diabetes.MethodsAn observational study enrolled pregnant women with type 1 diabetes who wore CGM devices during pregnancy and postpartum from 11 hospitals in China from January 2015 to June 2019. CGM data were collected to calculate time in range (TIR), time above range (TAR), time below range (TBR), and glycemic variability parameters. Relationships between the CGM metrics and HbA1c were explored. Linear and curvilinear regressions were conducted to investigate the best-fitting model to clarify the influence of HbA1c on the TIR-HbA1c relationship during pregnancy.ResultsA total of 272 CGM data and corresponding HbA1c from 98 pregnant women with type 1 diabetes and their clinical characteristics were analyzed in this study. Mean HbA1c and TIR were 6.49 ± 1.29% and 76.16 ± 17.97% during pregnancy, respectively. HbA1c was moderately correlated with TIR3.5-7.8(R = –0.429, P = .001), mean glucose (R = 0.405, P = .001) and TAR7.8 (R = 0.435, P = .001), but was weakly correlated with TBR3.5 (R = 0.034, P = .001) during pregnancy. On average, a 1% (11 mmol/mol) decrease in HbA1c corresponded to an 8.5% increase in TIR3.5–7.8. During pregnancy, HbA1c of 6.0%, 6.5%, and 7.0% were equivalent to a TIR3.5–7.8 of 78%, 74%, and 69%, respectively.ConclusionWe found there was a moderate correlation between HbA1c and TIR3.5–7.8 during pregnancy. To achieve the HbA1c target of less than 6.0%, pregnant women with type 1 diabetes should strive for a TIR3.5–7.8 of greater than 78% (18 hours 43 minutes) during pregnancy. |
| اللغة: | English |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5052da6c8f793c04093aabf5c14a5653Test http://europepmc.org/articles/PMC8530704Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5052da6c8f793c04093aabf5c14a5653 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
|---|