دورية أكاديمية
PLATELET SEROTONIN UPTAKE IS HIGHER IN EARLY-ONSET THAN IN LATE-ONSET ALCOHOLICS
| العنوان: | PLATELET SEROTONIN UPTAKE IS HIGHER IN EARLY-ONSET THAN IN LATE-ONSET ALCOHOLICS |
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| المؤلفون: | Javors, Martin, Tiouririne, Mohamed, Prihoda, Thomas |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2000 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | ORIGINAL ARTICLES |
| الوصف: | The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups ( P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://alcalc.oxfordjournals.org/cgi/content/short/35/4/390Test; http://dx.doi.org/10.1093/alcalc/35.4.390Test |
| DOI: | 10.1093/alcalc/35.4.390 |
| الإتاحة: | https://doi.org/10.1093/alcalc/35.4.390Test http://alcalc.oxfordjournals.org/cgi/content/short/35/4/390Test |
| حقوق: | Copyright (C) 2000, Medical Council on Alcohol |
| رقم الانضمام: | edsbas.30E86F7B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/alcalc/35.4.390 |
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